Results 221 to 230 of about 7,721,638 (300)

Evaluation of empirical and mechanistic models and sampling intervals to model the lactation curves of F1 dairy sheep. [PDF]

Trop Anim Health Prod
Guevara L, Lopez-Villalobos N, Pollott GE, Albarrán-Portillo B, Fernandes AM, Salinas-Martínez JA, Angeles-Hernandez JC.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Integrating information from historical data into mechanistic models for influenza forecasting. [PDF]

PLoS Comput Biol
Andronico A, Paireau J, Cauchemez S.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Deep neural networks for endemic measles dynamics: Comparative analysis and integration with mechanistic models. [PDF]

PLoS Comput Biol
Madden WG, Jin W, Lopman B, Zufle A, Dalziel B, E Metcalf CJ, Grenfell BT, Lau MSY.   +7 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons. [PDF]

J Neurosci
Dura-Bernal S, Herrera B, Lupascu C, Marsh BM, Gandolfi D, Marasco A, Neymotin S, Romani A, Solinas S, Bazhenov M, Hay E, Migliore M, Reinmann M, Arkhipov A.   +13 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mechanistic model of zooplankton

D3.3 Mechanistic model of zooplankton (M24, DTU). Code and documentation of trait-based model of the zooplankton (copepods) component of the marine ecosystem. Model will be coupled to unicellular model (D3.1) and to the transport matrix model (D1.2) to provide an estimate of functional diversity and key ecosystem metrics (export flux, trophic transfer ...
openaire   +1 more source

Mechanistic Models of Influenza Transmission in Commercial Swine Populations: A Systematic Review. [PDF]

Pathogens
Pittman Ratterree DC, Dass SC, Ndeffo-Mbah ML.   +2 more
europepmc   +1 more source