Results 231 to 240 of about 869,043 (286)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Mechanistic model of zooplankton

D3.3 Mechanistic model of zooplankton (M24, DTU). Code and documentation of trait-based model of the zooplankton (copepods) component of the marine ecosystem. Model will be coupled to unicellular model (D3.1) and to the transport matrix model (D1.2) to provide an estimate of functional diversity and key ecosystem metrics (export flux, trophic transfer ...
openaire   +1 more source

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Mechanistic Model of Gravitation

Lobachevskii Journal of Mathematics, 2023
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Belov, P. A., Lurie, S. A.
openaire   +1 more source

A mechanistic model for butyrylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1979
A plausible mechanism of action of horse serum butyrylcholinesterase is proposed. It includes substrate activation at the level of deacylation. The rate constant for the acylation of the enzyme appears to be much greater than the rate constant for the deacylation, at low substate concentrations.
H, Eriksson, K B, Augustinsson
openaire   +2 more sources

Mechanistic Models for Myelosuppression

Investigational New Drugs, 2003
As myelosuppression is the dose-limiting toxicity for most chemotherapeutic drugs, modelers attempt to find relationships between drug and toxicity to optimize treatment. Mechanistic models, i.e. models based on physiology and pharmacology, are preferable over empirical models, as prior information can be utilized and as they generally are more ...
Lena E, Friberg, Mats O, Karlsson
openaire   +2 more sources

The art of mechanistic modeling in biology

Nature Computational Science, 2022
A combination of experimental evaluation with computational modeling sheds light on how aging and limited lifespan influence population dynamics.
Ata Kalirad, Ralf J. Sommer
openaire   +3 more sources