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How Not to Make the Joint Extended Kalman Filter Fail with Unstructured Mechanistic Models. [PDF]
Sensors (Basel)Iglesias CF, Bolic M.
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Mechanistic Model of Gravitation
Lobachevskii Journal of Mathematics, 2023zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Belov, P. A., Lurie, S. A.
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The art of mechanistic modeling in biology
Nature Computational Science, 2022A combination of experimental evaluation with computational modeling sheds light on how aging and limited lifespan influence population dynamics.
Ata Kalirad, Ralf J. Sommer
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A mechanistic model for butyrylcholinesterase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1979A plausible mechanism of action of horse serum butyrylcholinesterase is proposed. It includes substrate activation at the level of deacylation. The rate constant for the acylation of the enzyme appears to be much greater than the rate constant for the deacylation, at low substate concentrations.
H, Eriksson, K B, Augustinsson
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Mechanistic Models for Myelosuppression
Investigational New Drugs, 2003As myelosuppression is the dose-limiting toxicity for most chemotherapeutic drugs, modelers attempt to find relationships between drug and toxicity to optimize treatment. Mechanistic models, i.e. models based on physiology and pharmacology, are preferable over empirical models, as prior information can be utilized and as they generally are more ...
Lena E, Friberg, Mats O, Karlsson
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A mechanistic model of a PDGFRα+ cell
Journal of Theoretical Biology, 2016A novel platelet-derived growth factor receptor alpha-positive cell (PDGFRα(+)) has recently been identified as part of the purinergic inhibitory neural control mechanism in the gastrointestinal (GI) tract. The mechanism through which PDGFRα(+) cells mediate GI muscle relaxation has been found to be associated with the purine receptors P2Y1 and apamin ...
Jing Wui, Yeoh +2 more
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A Mechanistic Model for Partial Preferences
Theoretical Population Biology, 2000Classic prey optimal foraging model assumes that individual predators are globally omniscient; that is, they have exact knowledge of prey population densities in the environment. This study examines a spatially explicit individual-based model of a one-predator two-prey system where individual predators are assumed to be omniscient only locally, i.e ...
Berec, Luděk, Křivan, Vlastimil
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Mechanistic biological modeling thrives
Science, 2016In their Perspective “Systems biology (un)certainties” (23 October 2015, p. [386][1]), P. D. W. Kirk et al. may give readers the impression that mathematical modeling and computer simulations of biological systems have fallen on hard times, owing to difficulties in measuring parameter values.
Ben, O'Shaughnessy, Thomas D, Pollard
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2009
Abstract The empiric models discussed heretofore have not explicitly incorporated knowledge of specific biological mechanisms, although in some cases, the form of the dose–response model may be motivated by theoretical considerations, such as the linear-quadratic cell-killing model used in radiobiology (see Chapter 6). In some instances,
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Abstract The empiric models discussed heretofore have not explicitly incorporated knowledge of specific biological mechanisms, although in some cases, the form of the dose–response model may be motivated by theoretical considerations, such as the linear-quadratic cell-killing model used in radiobiology (see Chapter 6). In some instances,
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