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Platelet Autophagy as a Druggable Intracellular Pathway: Therapeutic Opportunities in Thromboinflammatory Diseases. [PDF]

Pharmaceutics
Yen TL, Jan JS, Teng RD, Ko PC, Taliyan R, Yang CH, Sun JM, Sheu JR.   +7 more
europepmc   +1 more source

Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)

Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1)
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Effect of mechanistic/mammalian target of rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy

Effect of mechanistic/mammalian target of rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy
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Amino acid sensing and activation of mechanistic target of rapamycin complex 1

Current Opinion in Clinical Nutrition and Metabolic Care, 2016
This article evaluates recent studies on the mechanisms involved in sensing changes in amino acid availability and activation of the mechanistic target of rapamycin complex 1 (mTORC1).mTORC1 is sensitive to changes in amino acid availability and a well known regulator of protein turnover.
Daniel J, Ham, Gordon S, Lynch, René, Koopman   +2 more
openaire   +2 more sources

Targeting Mechanistic Target of Rapamycin Complex 1 Restricts Proinflammatory T Cell Differentiation and Ameliorates Takayasu Arteritis

Arthritis & Rheumatology, 2019
ObjectiveTakayasu arteritis (TAK) is a progressive autoimmune large vessel vasculitis with infiltration of proinflammatory T cells, with a largely unknown etiology. This study was undertaken to explore the involvement of mechanistic target of rapamycin (mTOR) in proinflammatory T cell differentiation and disease progression in TAK.MethodsNinety‐five ...
Jifeng Zhang, Lei Zhao, Jing Wang, Zhihua Cheng, Mengyao Sun, Jiayi Zhao, Bin Liu, Xiyu Liu, Zhenke Wen, Zhibo Li   +9 more
openaire   +2 more sources

Glutamine metabolism and interactions with mechanistic target of rapamycin complex 1 in porcine preimplantation embryos

2022
The ability to culture embryos has created opportunities for animal agriculture, including the refined selection of superior genetics, and for the medical field, allowing couples experiencing infertility to have biological children. Moreover, culturing embryos has led to the generation of numerous genetically modified models for improving production ...
openaire   +2 more sources

Linking Metabolic and Structural Remodeling by Cardiac‐Specific Activation of the Mechanistic Target Of Rapamycin Complex 1

The FASEB Journal, 2016
Background The heart remodels metabolically and structurally before it fails. Metabolically, the heart increases its reliance on carbohydrates for energy provision. Structurally, the heart hypertrophies to sustain increased hemodynamic stress.
Giovanni Davogustto, Rebecca Salazar, Hernan Vasquez, Heinrich Taegtmeyer   +3 more
openaire   +1 more source

Sirtuins in mechanistic target of rapamycin complex 1 signaling

2021
J. Burillo, P. Marqués, B. Jiménez, C. González-Blanco, M. Benito, C. Guillén   +5 more
openaire   +1 more source

Mechanistic/Mammalian Target of Rapamycin Complex 1 Signaling Network

2021
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Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development

Autophagy, 2020
Tsuyoshi Kawabata, Kazumi Taguchi, Shuzo Hamamoto   +2 more
exaly