Results 181 to 190 of about 5,025 (229)

NMR studies of the conjugation of mechlorethamine with glutathione

Journal of Medicinal Chemistry, 1990
Many cancer cells are resistant to chemotherapeutic treatment with mechlorethamine and other alkylating agents. These drug-resistant cells often show an increase in the intracellular concentration of glutathione and an increase in the activity of glutathione-S-transferase when compared to the sensitive cells.
Michael E. Colvin, Terence G. Hamill, Michael P. Gamcsik   +2 more
openaire   +3 more sources

Studies in the Pharmacodynamics of Mechlorethamine and AB 100

JAMA, 1961
ALKYLATING agents have been used in the Ltreatment of neoplastic disease since 1931, when Adair and Bagg 1 described experiences with topical application of sulfur mustard. Intensive investigation during World War II resulted in a greater appreciation of the usefulness of these compounds.
Herman Hagedorn, Robert K. Ausman, George E. Crevar, Thomas J. Bardos, J. L. Ambrus   +4 more
openaire   +3 more sources

Topical mechlorethamine therapy for mycosis fungoides

British Journal of Dermatology, 1977
Patients with limited skin involvement by mycosis fungoides were treated with daily topical mechlorethamine. Seven of thirteen patients had a complete remission of diseases. Six of these seven experienced a contact dermatitis and four underwent a successful topical desensitization programme.
Zvi Fuks, Victor S. Constantine, Norman M. Price, Norman M. Price, Richard T. Hoppe, Eugene M. Farber   +5 more
openaire   +3 more sources

Failure to Induce Tolerance to Mechlorethamine Hydrochloride

Archives of Dermatology, 1977
In view of the contradictory results reported in the literature regarding induction of specific immunologic tolerance to mechlorethamine hydrochloride (HN2), the problem was reinvestigated using a "tolerogenic" schedule that had been reported to be effective.
Rudolf L. Baer, Roberta S. Simon, Steven M. Leshaw   +2 more
openaire   +3 more sources

Cytotoxicity and pharmacokinetics study of nanostructured lipid carriers of mechlorethamine: Preparation, optimization and characterization

Particulate Science and Technology, 2020
The present work was aimed to prepare, optimize and characterize nanostructured lipid carriers (NLCs) loaded with mechlorethamine for improvement in pharmacokinetics.
B. Gidwani, A. Vyas, C. Kaur
semanticscholar   +1 more source

Topically Applied Mechlorethamine in the Treatment of Psoriasis

Archives of Dermatology, 1971
The psoriatic lesions of seven male patients were treated with a daily topical application of 10 mg of mechlorethamine hydrochloride in 50 ml of tap water. All seven patients began to show resolution of the treated lesions within seven days, with essentially complete clearing of the lesions by three weeks.
J. Richard Taylor, Stephen H. Mandy, Kenneth M. Halprin   +2 more
openaire   +3 more sources

Response of Mycosis Fungoides to Topical Chemotherapy With Mechlorethamine [PDF]

Archives of Dermatology, 1984
Seventy-six patients with mycosis fungoides (MF) were given topical mechlorethamine hydrochloride therapy. Allergic contact hypersensitivity reactions to the drug developed in 51 patients (67.1%). Sixty-four patients of the original 76 continued therapy, with 43 (67.2%) achieving a complete remission and 12 (18.8%) achieving a partial remission.
Robert E. Parnes, Neil Dubin, David L. Ramsay   +2 more
openaire   +2 more sources

Counteraction of leukopenia caused by mechlorethamine and azathioprine

Journal of Surgical Oncology, 1971
AbstractPCO, a deproteinized yeast extract of low toxicity, increases tissue respiration, offsets the toxicity of mechlorethamine hydrochloride (HN2) for mice with maintenance of antineoplastic activity in the systems studied, and is a useful adjuvant to azathioprine in dog renal allografts. The two latter effects appear to be related to the ability of
Leo G. Nutini, Elton S. Cook
openaire   +3 more sources

Intravenous Desensitization to Mechlorethamine in Patients With Psoriasis

Archives of Dermatology, 1976
Eight patients with psoriasis who had developed contact allergy to mechlorethamine hydrochloride (nitrogen mustard) were subjected to a regimen of intravenous infusion of small amounts of the drug in an attempt to produce desensitization. Although three of eight developed negative patch tests and were presumed to be desensitized, only one patient was ...
Kenneth M. Halprin, Richard C. Childers, David M. Pariser, J. Richard Taylor, Paul Kechijian   +4 more
openaire   +3 more sources

Mechlorethamine Desensitization in Therapy for Mycosis Fungoides

Archives of Dermatology, 1975
Five patients with mycosis fungoides who had developed contact dermatitis to a nitrogen mustard, mechlorethamine hydrochloride, even in low concentrations (1 to 5 mg/100 ml), received daily total-body applications of extremely dilute solutions (0.01 to 0.1 mg/100 ml) of mechlorethamine.
Zvi Fuks, Eugene M. Farber, Victor S. Constantine   +2 more
openaire   +3 more sources