Results 111 to 120 of about 21,530 (241)

Comparative Pharmacokinetics of Intranasal or Intramuscular Atipamezole in Unsedated Dogs and Efficacy for Reversal of Xylazine Sedation

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The objectives of this study were to evaluate ATIP pharmacokinetics (PK) in healthy Beagle dogs after IM and IN dosing (Phase I), and to compare the rate of reversal of IM versus IN routes for xylazine (XYL) sedation (Phase II). This study was comprised of two sequential, randomized, crossover experiments. The initial PK study dosed ATIP by IN
Vanessa E. Cowan   +7 more
wiley   +1 more source

Effect of Butorphanol-Medetomidine and Butorphanol-Dexmedetomidine on Echocardiographic Parameters during Propofol Anaesthesia in Dogs

open access: yesAnimals
This study compared the effects of butorphanol-medetomidine and butorphanol-dexmedetomidine combinations on echocardiographic parameters during propofol anaesthesia in dogs. The dogs were randomly divided into two groups. In the butorphanol-medetomidine (
Andrej Bočkay   +4 more
doaj   +1 more source

Exposure to Subcutaneously Administered Butorphanol in Horses Pre‐Treated With Detomidine or Detomidine‐Vatinoxan

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The aim of the study was to determine the exposure to subcutaneously administered butorphanol in horses pre‐treated with intravenous (IV) detomidine, with or without vatinoxan, a peripherally selective alpha2‐adrenoceptor antagonist. Five healthy, adult horses received three IV treatments 7 days apart, in a randomized, cross‐over design ...
Juhana M. Honkavaara   +5 more
wiley   +1 more source

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant   +9 more
wiley   +1 more source

Investigation of 222‐nm ultraviolet C irradiation bactericidal effect on the surgical field in a rabbit model

open access: yesPhotochemistry and Photobiology, EarlyView.
In a rabbit surgical field model seeded with polymicrobial flora, a single dose of 222‐nm UV‐C (500 mJ/cm2) markedly reduced bacterial colonies, achieving a bactericidal effect comparable to 254‐nm UV‐C (200 mJ/cm2), while no UV‐C irradiation showed heavy growth. Wound healing did not differ among groups. Microbiota profiling detected SSI‐relevant taxa
Tomoaki Fukui   +11 more
wiley   +1 more source

Artificial Irrigation Impacts the Seasonal Occurrence of Pathogenic Leptospira in Its Wild Reservoirs in a Mediterranean Environment

open access: yesZoonoses and Public Health, EarlyView.
ABSTRACT Background Human activities play a significant role in the emergence of infectious diseases. We aimed to test whether artificial irrigation affects the occurrence of a zoonotic bacteria sensitive to desiccation, pathogenic Leptospira species (pathoLep), in micromammals inhabiting Mediterranean ecosystems.
Cristina Ruiz   +4 more
wiley   +1 more source

Sound offset responses become highly informative in the auditory cortex

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Using large datasets of neural responses to diverse sounds recorded across four stages of the mouse auditory system (depicted and colour‐coded on the left), offset responses occurring after the termination of each sound (time window indicated by the orange shaded area superimposed with activity traces) were characterized and it ...
Charly Lamothe   +3 more
wiley   +1 more source

Evaluation of Recovery Time and Quality After Two Different Post-Operative Doses of Medetomidine in Spanish Purebred Horses Anaesthetized with Medetomidine–Isoflurane Partial Intravenous Anaesthesia

open access: yesAnimals
Recovery from general anaesthesia is risky in horses. Alpha2-agonist administration after anaesthesia enhances the quality of recovery but may prolong this phase. Recovery time and quality were investigated after medetomidine administration at the end of
Francisco Medina-Bautista   +6 more
doaj   +1 more source

Panoramic voltage‐sensitive optical mapping of contracting hearts using cooperative multiview motion tracking with 12 cameras

open access: yesThe Journal of Physiology, EarlyView.
Abstact figure legend A panoramic 3D optical mapping system was developed, enabling imaging of action potential waves across the entire strongly deforming ventricular surface of beating isolated hearts. The system comprises 12 high‐speed cameras and a soccerball‐shaped imaging chamber with 48 light‐emitting diodes (LEDs).
Shrey Chowdhary   +5 more
wiley   +1 more source

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