Results 71 to 80 of about 13,656 (235)

Comparison of thiafentanil-medetomidine to etorphine-medetomidine immobilisation of impalas (Aepyceros melampus).

Journal of the South African Veterinary Association, 2017
Impalas (Aepyceros melampus) are increasingly valuable in the South African wildlife industry, and there is a greater need to chemically immobilise them, ideally with minimal risk. This study aimed to compare the times to recumbency and physiological effects of thiafentanilmedetomidine versus etorphine-medetomidine immobilisation.
Zeiler, Gareth Edward, Meyer, Leith Carl Rodney   +1 more
openaire   +4 more sources

First Vasectomy Procedure Successfully Performed on a Southern African Male Giraffe (Giraffa camelopardalis giraffa)

Zoo Biology, EarlyView.
First successful vasectomy in a southern African male giraffe, Giraffa camelopardis giraffa ABSTRACT This study reports the first successful vasectomy on a southern African male giraffe (Giraffa camelopardalis giraffa). The goal of the procedure was to create a teaser male for reproductive studies.
Francois Deacon, Willem Daffue, Edward Collin Albertyn, Susanna Maria Krüger, Ayanda Maqhashu, Jacquiline Goedhals, Andri Grobbelaar, Marike Badenhorst   +7 more
wiley   +1 more source

Decreased Effectiveness of a Novel Opioid Withdrawal Protocol Following the Emergence of Medetomidine as a Fentanyl Adulterant

BioMed
Background/Objectives: Philadelphia has experienced a surge in illicit fentanyl adulterated with alpha-2 agonist sedatives. Initially, xylazine (“tranq”) was the predominant adulterant, and a novel multimodal withdrawal protocol was effective at ...
Kory S. London, Philip Durney, TaReva Warrick-Stone, Karen Alexander, Jennifer L. Kahoud   +4 more
doaj   +1 more source

Therapeutic Efficacy of the Supersulfide Donor NAC‐S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses

Microbiology and Immunology, EarlyView.
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Foysal Hossen, Takahisa Kouwaki, Yukio Fujiwara, Hiroyasu Tsutsuki, Tianli Zhang, Chunyu Guo, Azizur Rahman, Yoshihiro Komohara, Hiroyuki Oshiumi, Tomohiro Sawa   +9 more
wiley   +1 more source

Dexmedetomidine – Commonly Used in Functional Imaging Studies – Increases Susceptibility to Seizures in Rats But Not in Wild Type Mice

Frontiers in Neuroscience, 2020
Functional MRI (fMRI) utilizes changes in metabolic and hemodynamic signals to indirectly infer the underlying local changes in neuronal activity. To investigate the mechanisms of fMRI responses, spontaneous fluctuations, and functional connectivity in ...
Aleksandra Bortel, Aleksandra Bortel, Roland Pilgram, Roland Pilgram, Ze Shan Yao, Ze Shan Yao, Amir Shmuel, Amir Shmuel, Amir Shmuel   +8 more
doaj   +1 more source

Sedative Effects of Medetomidine in Pigs.

Journal of Veterinary Medical Science, 1992
Sedative effects of medetomidine, a potent selective and specific alpha 2-adrenoceptor agonist, were evaluated in pigs using 5 different doses (30, 50, 80, 100 and 150 micrograms/kg of body weight) and compared with those of xylazine (2 mg/kg). Atropine (25 micrograms/kg) was mixed with both drugs to prevent severe bradycardia.
M, Sakaguchi, R, Nishimura, N, Sasaki, T, Ishiguro, H, Tamura, A, Takeuchi   +5 more
openaire   +3 more sources

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, EarlyView.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Effect of Medetomidine and Combination of Medetomidine/tiletamine/zolazepam and Medetomidine/tiletamine/zolazepam/tramadol on Echocardiographic Cardiac Contractility in Dogs

Journal of Veterinary Clinics, 2015
This study evaluated the myocardial performance on echocardiography after the sedation/anesthesia of medetomidine (D), the combination of medetomidine and tiletamine/zolazepam (DZ), and the combination of medetomidine, tiletamine/zolazepam and tramadol (DZT) in Beagle dogs.
Sang-IL Suh, Tae-Jun Kim, Eun-Chan Lee, Changbaig Hyun   +3 more
openaire   +1 more source