Results 81 to 90 of about 21,530 (241)

Influence of dexmedetomidine-propofol-isoflurane and medetomidine-propofol-isoflurane on intraocular pressure and pupil size in healthy dogs

Veterinární Medicína, 2016
The present prospective, randomised, double-blinded clinical study was designed to investigate the commonly used anaesthetic combinations of dexmedetomidine-propofol-isoflurane and medetomidine-propofol-isoflurane on intraocular pressure and pupil size ...
P. Rauser, M. Mrazova, J. Zapletalova
doaj   +1 more source

The Effect of Medetomidine on the Burying Speed of Corbicula fluminea

, 2012
A new anti-fouling drug, medetomidine, was tested to determine if it reduced the burying speed of a freshwater alien-invasive bivalve species, Corbicula fluminea.
Schmucker, Andrew K.
core  

Comparison of thiafentanil-medetomidine to etorphine-medetomidine immobilisation of impalas (Aepyceros melampus).

Journal of the South African Veterinary Association, 2017
Impalas (Aepyceros melampus) are increasingly valuable in the South African wildlife industry, and there is a greater need to chemically immobilise them, ideally with minimal risk. This study aimed to compare the times to recumbency and physiological effects of thiafentanilmedetomidine versus etorphine-medetomidine immobilisation.
Zeiler, Gareth Edward, Meyer, Leith Carl Rodney   +1 more
openaire   +4 more sources

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Structure and Dynamics of Brain Lobes Functional Networks at the Onset of Anesthesia Induced Loss of Consciousness

, 2016
Anesthetic agents are neurotropic drugs able to induce dramatic alterations in the thalamo-cortical system, promoting a drastic reduction in awareness and level of consciousness.
Padovani, Eduardo C.
core  

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, EarlyView.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Dexmedetomidine – Commonly Used in Functional Imaging Studies – Increases Susceptibility to Seizures in Rats But Not in Wild Type Mice

Frontiers in Neuroscience, 2020
Functional MRI (fMRI) utilizes changes in metabolic and hemodynamic signals to indirectly infer the underlying local changes in neuronal activity. To investigate the mechanisms of fMRI responses, spontaneous fluctuations, and functional connectivity in ...
Aleksandra Bortel, Aleksandra Bortel, Roland Pilgram, Roland Pilgram, Ze Shan Yao, Ze Shan Yao, Amir Shmuel, Amir Shmuel, Amir Shmuel   +8 more
doaj   +1 more source

Sedative Effects of Medetomidine in Pigs.

Journal of Veterinary Medical Science, 1992
Sedative effects of medetomidine, a potent selective and specific alpha 2-adrenoceptor agonist, were evaluated in pigs using 5 different doses (30, 50, 80, 100 and 150 micrograms/kg of body weight) and compared with those of xylazine (2 mg/kg). Atropine (25 micrograms/kg) was mixed with both drugs to prevent severe bradycardia.
M, Sakaguchi, R, Nishimura, N, Sasaki, T, Ishiguro, H, Tamura, A, Takeuchi   +5 more
openaire   +3 more sources

Growth differentiation factor 15 mitigates lipotoxic steatosis by preserving mitochondrial morphodynamics and augmenting fatty acid oxidation in hepatocytes and liver organoids

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Growth differentiation factor 15 (GDF15) has emerged as a promising metabolic regulator with hepatoprotective properties in metabolic dysfunction‐associated steatotic liver disease (MASLD), yet its underlying mechanisms remain elusive.
Jia Li, Qi Zhou, Mengmeng Xia, Yakun Li, Junyu Wang, Manon Buist‐Homan, Vincent E. de Meijer, Hans Blokzijl, Klaas Nico Faber, Han Moshage   +9 more
wiley   +1 more source

Characterization of the Community Structure of Large Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction

, 2016
One of the central questions in neuroscience is to understand the way communication is organized in the brain, trying to comprehend how cognitive capacities or physiological states of the organism are potentially related to brain activities involving ...
Padovani, Eduardo C.
core