Results 131 to 140 of about 4,586,937 (332)

Accessibility in online exhibitions of Brazilian science museums and centers: identifying strategies and barriers

Frontiers in Education
Science museums and exhibitions play a crucial role in formal and non-formal education and in the communication of science. However, access to online science exhibitions is still limited.
Jessica Norberto Rocha, Jessica Norberto Rocha, Letícia Marinho, Letícia Marinho, Gabriela Heck, Gabriela Heck, Marcelle Pita de Sousa Carmo, Marcelle Pita de Sousa Carmo, Willian Vieira de Abreu, Willian Vieira de Abreu   +9 more
doaj   +1 more source

Learner-centred Accessibility for Interoperable Web-based Educational Systems [PDF]

, 2005
This paper describes the need for an information model and specifications that support a new strategy for delivering accessible computer-based resources to learners based on their specific needs and preferences in the circumstances in which they are ...
Andy Heath, Jutta Treviranus, La Trobe, Liddy Nevile, Madeleine Rothberg, Martyn Cooper   +5 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Embracing community-based participatory research in Media Accessibility

JoSTrans: The Journal of Specialised Translation, 2023
Irene Hermosa-Ramírez
doaj   +1 more source

Pathways to understanding problem gambling among adolescents

BMC Public Health
Background Gambling among youth is attracting the attention of health experts worldwide. A need has arisen for more research on the pathways to the development of adolescent problem gambling behavior and related factors.
Hyun Jung Lee, Gyungjoo Lee
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Student Perceptions of Desired Learning Media Technology Development

Jurnal Teknologi Pendidikan
This study aimed to explore the perceptions of undergraduate students on suitable learning media for website development. A qualitative method with a case study type was used in this research. Fifty undergraduate students from the Educational Technology
Andayani, Suryo Prabowo, Abd Gafur, Robinson Situmorang, Bramianto Setiawan   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes. [PDF]

, 2018
Maintenance of transcription programs is challenged during mitosis when chromatin becomes condensed and transcription is silenced. How do the daughter cells re-establish the original transcription program?
An, Luye, Bhargava-Shah, Aarohi, Darzacq, Xavier, Teves, Sheila S, Tjian, Robert, Xie, Liangqi   +5 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source