Results 131 to 140 of about 192,651 (303)
Insider research in media accessibility
Reflections on insider research, user-led research, and lived experience research, as well as the question of positionality, have long been part of the scholarly conversation in various fields, such as Anthropology and Disability Studies.
Boukala, Mouloud +1 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Understanding Media Accessibility Quality (UMAQ)
, 2017 Media Accessibility (MA) is at the core of the most pressing priorities of the European Commission, such as the European Disability Strategy 2010-2020 and the Digital Single Market Strategy. For a long time, policies involving MA have been concerned with
Greco, Gian Maria, Orero, Pilar
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Teaching media accessibility : three case-studies [PDF]
, 2013 Media access and information access have been part of a proactive policy at different UAB sectors, from student's welfare office, building administration and architecture to research and training.
Orero, Pilar, Matamala, Anna
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A review of "Embracing community-based participatory research in Media Accessibility"
JoSTrans: The Journal of Specialised Translation, 2023 William Brown
doaj +1 more source
Ensuring Equal Access, Collaborating on Accessibility
, 2015 When the Libraries User Experience and Digital Media Services Group reached out to the Assistive Technology and Accessibility Centers (ATAC) for an accessibility evaluation, they did not realize this first consultation would morph into a long term ...
Humbert, Joe +3 more
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