Results 241 to 250 of about 4,334,118 (337)

Single-cell multi-omics identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma. [PDF]

Nat Commun
Veo B, Wang D, DeSisto J, Pierce A, Brunt B, Bompada PC, Donson A, Goodspeed A, Smart K, Foreman N, Dahl N, Vibhakar R.   +11 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

My accessible media

, 2020
openaire   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer. [PDF]

Genes Dev
Garcia-Martinez L, Zha M, Borges RL, Liu T, González-Blanco G, Martinez Alonso A, Stransky S, Sidoli S, Zhu H, Wang Z, Morey L.   +10 more
europepmc   +1 more source

Barriers to accessibility and availability of safe abortion services among young women in Nepal: a mixed-methods study. [PDF]

BMC Public Health
Ghimire R, Sharma S, Singh A, Bhusal R, Tamang L.   +4 more
europepmc   +1 more source

How Can We Size Your Core Issue? Assessing Salience Validity Using Psychophysiology. [PDF]

Public Opin Q
Tremblay-Antoine C, Dufresne Y, Vachon F.   +2 more
europepmc   +1 more source