Results 101 to 110 of about 1,479,356 (306)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Theoretical features of the integration of media centers in the conditions of modern schools development

Неофилология
INTRODUCTION. The theoretical aspects of integrating media centers in modern Russian schools and their role in modernizing media consumption structures are explored.
P. A. Vakker
doaj   +1 more source

Visual stimulation by extensive visual media consumption can be beneficial for motor learning. [PDF]

Sci Rep, 2023
Nuernberger M, Finke K, Nuernberger L, Ruiz-Rizzo AL, Gaser C, Klingner C, Witte OW, Brodoehl S.   +7 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

New media literacy of communication faculty students in Kyrgyzstan: an investigation in the context of demographic variables

Cogent Education
This study aims to determine the new media literacy levels of communication faculty students in Kyrgyzstan and to examine the relationship between these levels and demographic variables such as age, gender, class and internet usage time. The research was
Niyazi Ayhan, Erdoğan Akman
doaj   +1 more source

Long-Run Effects of BSE on Meat Consumption [PDF]

This paper considers the long-run effects of BSE on meat consumption in the United Kingdom using data from the Expenditure and Food Survey. We estimate a dynamic AIDS demand system of household food consumption, with long-run effects captured via an ...
Adam Bialowas, Cain Polidano, Lisa Farrell, Mark N. Harris   +3 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Consuming fear as entertainment: horror movies, youth culture, and the social production of fear in contemporary media contexts

Frontiers in Communication
This study explores how fear is generated, experienced, and normalized as a form of entertainment within contemporary media culture, particularly among adolescents.
Aep Wahyudin, Lucy Pujasari Supratman
doaj   +1 more source