Results 41 to 50 of about 18,170,611 (288)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

The quantity and quality of the media coverage of women's and men's basketball in Slovenia

Kinesiologia Slovenica, 2008
The study aimed to analyse the media coverage of women’s and men’s basketball in Slovenia and establish the quantity and quality of the media coverage of women’s basketball compared to men’s. The study was made on a sample of 81 basketball experts.
Mojca Doupona Topič, Frane Erčulj
doaj   +1 more source

Spain’s «national character» in «The Economist»

Communication & Society (Formerly Comunicación y Sociedad), 2023
The image of a country conveyed by the international media is increasingly important in a globalised and interdependent world. Some of these international outlets have a special role to play in this process, and the British weekly The Economist is ...
Ángel Arrese, James Breiner
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

THE IMPACT OF MEDIA COVERAGE ON THE COURSE OF CRIMINAL PROCEEDINGS AND THE RIGHTS OF PARTICIPANTS

Хабаршы. Заң сериясы
This article investigates the impact of media coverage on criminal trials and their participants, with particular attention paid to digitalization and social networks as sources of coverage.
А.Ж. Муратова, И.С. Сактаганова, А.Б. Сактаганова, А.Е. Есеналиев, Р. Токанова   +4 more
doaj   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The impact of the economic crisis on media framing : evidence from three elections in Ireland [PDF]

, 2014
Media coverage of elections in Europe and North America has increasingly focused on the campaign as a game rather than a policy debate. This is often explained by the changes in media pressures.
Rafter, Kevin, Brandenburg, Heinz, Flynn, Roddy, McMenamin, Ian, O'Malley, Eoin   +4 more
core   +4 more sources

The impact of media coverage on the ESG performance of heavily polluting enterprises in China

Discover Sustainability
Based on panel data from 2011 to 2021 encompassing 390 listed enterprises in China, we investigate the potential influence of media coverage on the Environmental, Social, and Governance (ESG) performance of heavy-polluting enterprises. The study discerns
Sen Li, Han Long
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source