Results 61 to 70 of about 260,473 (265)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Our House Is Burning: Discrepancy in Climate Change vs. Biodiversity Coverage in the Media as Compared to Scientific Literature

Frontiers in Ecology and Evolution, 2018
Scientists, policy makers, and journalists are three key, interconnected players involved in prioritizing and implementing solutions to mitigate the consequences of anthropogenic pressures on the environment.
Pierre Legagneux, Nicolas Casajus, Kevin Cazelles, Clément Chevallier, Marion Chevrinais, Lorelei Guéry, Claire Jacquet, Claire Jacquet, Mikael Jaffré, Marie-José Naud, Fanny Noisette, Pascale Ropars, Pascale Ropars, Steve Vissault, Philippe Archambault, Joel Bêty, Dominique Berteaux, Dominique Gravel   +17 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Disaster, uncertainty, opportunity or risk? Key messages from the television coverage of the IPCC’s 2013/2014 reports

Mètode Science Studies Journal: Annual Review, 2016
This article examines the television coverage of the three 2013 and 2014 reports by the Working Groups of the IPCC in five European countries: Germany, Norway, Poland, Spain and the United Kingdom.
James Painter
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

ABUJA RESIDENTS’ PERCEPTION OF MASS MEDIA COVERAGE OF THE 2023 PRESIDENTIAL ELECTION CAMPAIGN IN NIGERIA

International Studies Journal
This study assessed Abuja residents’ perception of mass media coverage of the 2023 Presidential election campaign in Nigeria. Previous studies have either looked at print media, broadcast media or social media coverage of elections in Nigeria.
DANIEL T. EZEGWU, AGNES. O. EZEJI, GLORIA NWAKEGO CHUKWUEMEKA, CHIOMA ROSE CHIME-NGANYA   +3 more
doaj  

When Politics and Religion Fuse: The Nature and Implications of the Meskel Square Controversy in the Ethiopian Media

Religions
Using space as a conceptual framework, this paper analyzes the nature of a controversy that arose in Ethiopia when the government and three religious groups—the Ethiopian Orthodox Tewahedo Church (EOTC), Protestants and Muslims—clashed over claims to ...
Sileshie Semahagne Kumlachew
doaj   +1 more source

Role of Media and Effects of Infodemics and Escapes in the Spatial Spread of Epidemics: A Stochastic Multi-Region Model with Optimal Control Approach

Mathematics, 2019
Mass vaccination campaigns play major roles in the war against epidemics. Such prevention strategies cannot always reach their goals significantly without the help of media and awareness campaigns used to prevent contacts between susceptible and infected
Fadwa El Kihal, Imane Abouelkheir, Mostafa Rachik, Ilias Elmouki   +3 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source