Results 111 to 120 of about 3,812,995 (305)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Educating generation next: screen media use, digital competencies and tertiary education [PDF]
, 2015 Investigates the use of screen media and digital competencies of higher education students in light of the growing focus on new media and e-learning in Australian universities.
Adam Brown, Toija Cinque
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Journalism and MediaBased on Agenda-Setting Theory, Media Agenda Synergy (MAS) can enhance the communication effectiveness of public issues (e.g., climate change, social justice, and public health) through the information resonance and agenda complementarity among cross ...
Shuang Feng +2 more
doaj +1 more source
Social Media Enters the Mainstream: Report on the Use of Social Media in Advancement, 2014 [PDF]
, 2014 Social media use is becoming increasingly engrained in the work of alumni relations, communications, fundraising and marketing professionals at educational institutions, according to results cited in a new white paper.
Jennifer Mack, Michael Stoner
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Exploring fonts as retrieval cues in text-based learning
Acta PsychologicaA growing body of research focuses on optimizing retrieval processes to help learners recall information from memory. The context-dependent memory effect suggests that information retrieval is more effective when the retrieval context matches the ...
Felix Krieglstein +6 more
doaj +1 more source
Currents: Bad for Divers, Good for Corals [PDF]
In this lesson students will investigate deep-sea currents such as density and barotropic currents, which can be significantly accelerated near the ocean bottom or near large solid objects like seamounts.
Mel Goodwin
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source