Results 111 to 120 of about 3,850,169 (303)

A Watered-Down Topographic Map [PDF]

open access: yes
In this activity, students will learn how topographic maps are created and investigate the differences between topographic maps and bathymetric charts. They will understand how a two-dimensional map can show both the vertical and the horizontal shape of ...

core  

Media Usage in Post-Secondary Education and Implications for Teaching and Learning

open access: yes, 2014
The Web 2.0 has permeated academic life. The use of online information services in post-secondary education has led to dramatic changes in faculty teaching methods as well as in the learning and study behavior of students.
Capretz, Luiz Fernando   +3 more
core   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Students’ Expectations and Experiences of Meaningful Simulation-Based Medical Education

open access: yesSeminar.net, 2016
This study aims to investigate students’ expectations and experiences of meaningful learning in simulation-based learning environments. We set the following research question: How do students’ experiences of meaningful simulation-based learning ...
Tuulikki Keskitalo, Heli Ruokamo
doaj  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Measuring Digital Stress in Children: Construct Validity, Model Comparisons, and Measurement Invariance of a Multidimensional Scale (DSS-CH)

open access: yesChildren
Background: The use of digital media in childhood offers both opportunities and risks. Digital stressors—such as excessive screen time, constant availability, information overload, and social media pressures—affect primary school children but have been ...
Arvid Nagel, Felix Kruse
doaj   +1 more source

Submersible Designer [PDF]

open access: yes
In this lesson students will discover how a submersible's design enables humans to explore the deep ocean. As a result of doing this activity, students will understand that the physical features of water can be restrictive to movement.

core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy