Results 51 to 60 of about 1,079,714 (313)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Research Resiliency through Lean Labs

open access: yesAdvanced Intelligent Systems, 2020
Academic research groups, especially the ones directed by new junior faculty are under pressure to produce high‐quality work timely while constrained by limited budget, resources, and lab space. A well‐organized lab is crucial for a wide range of reasons,
Canan Dagdeviren   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Media reform: in shallows and miseries [PDF]

open access: yes, 2013
This paper recounts the story of the 2013 media reforms - their introduction, the hurried investigations which attempted to explore their intentions and possible outcomes, and their eventual demise. Introduction As a result of an investigation into the
Rhonda Jolly
core  

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

Genealogies of Environmental Media: Feminist Art and the Choreographic Body in Social Works

open access: yesMedia + Environment, 2022
"Genealogies of Environmental Media" analyzes a feminist genealogy of art and media practice that reconstitutes the relationship between bodies and environments through what Shannon Jackson calls "social works"---artworks that are engaged at the nexus of
Sarah Lerner
doaj   +1 more source

Urban digital media: facilitating the intersection between science, the arts and culture in the arena of technology and building [PDF]

open access: yes, 2010
The research presented in this paper investigates ways of providing better design applications for technologies in the field of Urban Digital Media (UDM).
Haeusler, M   +5 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

The macro-environment for liquid biofuels in the German science, mass, media and government

open access: yes, 2010
The purpose of this study is to investigate under which dimensions the macro-environment for liquid biofuels has been structured during time, respectively by science, mass media, and government in Germany, and how these three social expressions related ...
Dewes, H., Talamini, E., Wubben, E.F.M.
core  

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