Results 121 to 130 of about 66,044 (308)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Gender differences in job satisfaction among gig workers in Bangladesh

Scientific Reports
The gig economy (temporary, contract, and freelance online jobs rather than permanent positions) is a component of the fourth industrial revolution and preview of future work.
Mou Rani Sarker, Tanjum Afrin Taj, Md Abdur Rouf Sarkar, Md. Fuad Hassan, Andrew M. McKenzie, Md. Abdullah Al Mamun, Dweep Sarker, Humnath Bhandari   +7 more
doaj   +1 more source

The price of freedom: the opportunities and constraints of freelance employment for older workers : a study of media professionals [PDF]

, 2002
The UK's population is ageing at a time when its oldest workers are leaving the labour market at progressively younger ages. This paradox - of declining economic activity rates among the 50 plus age group and rising longevity - has led to widespread concern over the social and economic consequences . Meanwhile, flexible work has grown in the UK economy
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

PERSONAL BRANDING OF FREELANCE MAKE UP ARTIST (MUA) IN PEKANBARU CITY ON INSTAGRAM SOCIAL MEDIA

Jurnal Netnografi Komunikasi
Searching for MUA services in the digital era is now easy, with many choices on social media such as Instagram, which allows searches based on domicile, price, characteristics or quality. This research aims to analyze the personal branding of freelance MUAs in Pekanbaru via Instagram, using Montoya's personal branding theory with eight indicators ...
null Suci Shinta Lestari, null Mutia Farina   +1 more
openaire   +1 more source

A Report on the Design Sub-Sector in London [PDF]

, 2008
Housed in the School of Creative Enterprise at the London College of Communication (University of the Arts), the Creative Industries Observatory (CIO) is a leading contributor to academic research and analysis within the creative industries, and a source
Cardoso, Eva, Carnicero, Laura, Dempster, Anna, Joel, Sian, Liu, Kai, Mould, Oli, Pezzana, Silvio Pierluigi, Roodhouse, Simon   +7 more
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Understanding Consumer’s Attitude on Fish Quality and Marketing Aspects in the Greek Market [PDF]

During the last decade the Greek fish market experienced significant changes affecting both the supply and the demand of fish. Fisheries have faced significant problems, such as overfishing and low productivity.
Batzios, Christos, Moutopoulos, D.K., Siardos, G.   +2 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source