Results 121 to 130 of about 66,147 (308)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Dans l’atelier de la chercheuse: Commenter étudier les violences contre les journalistes ?

Sur le Journalisme
FR. Cet article examine les choix méthodologiques posés dans le cadre d’une étude sur les violences et les expériences d’insécurité vécues par les journalistes francophones en Belgique. J’y explique comment mes postures d’ex-pigiste, mais aussi de femme,
Clémence Petit
doaj   +1 more source

The price of freedom: the opportunities and constraints of freelance employment for older workers : a study of media professionals [PDF]

, 2002
The UK's population is ageing at a time when its oldest workers are leaving the labour market at progressively younger ages. This paradox - of declining economic activity rates among the 50 plus age group and rising longevity - has led to widespread concern over the social and economic consequences . Meanwhile, flexible work has grown in the UK economy
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Foreign correspondence from Sub-Saharan Africa: An evolving communicational paradigm shift / Corresponsales extranjeros en África Subsahariana: Un paradigma comunicativo en evolución

Index Comunicación, 2013
A sizable portion of our everyday knowledge about Sub-Saharan Africa comes from the work of international news reporters. Even though these news actors play a critical role in the communication of the distant Other, frequently criticized for its ...
Paulo Nuno Vicente, Universidade Nova de Lisboa   +1 more
doaj  

PERSONAL BRANDING OF FREELANCE MAKE UP ARTIST (MUA) IN PEKANBARU CITY ON INSTAGRAM SOCIAL MEDIA

Jurnal Netnografi Komunikasi
Searching for MUA services in the digital era is now easy, with many choices on social media such as Instagram, which allows searches based on domicile, price, characteristics or quality. This research aims to analyze the personal branding of freelance MUAs in Pekanbaru via Instagram, using Montoya's personal branding theory with eight indicators ...
null Suci Shinta Lestari, null Mutia Farina   +1 more
openaire   +1 more source

A Report on the Design Sub-Sector in London [PDF]

, 2008
Housed in the School of Creative Enterprise at the London College of Communication (University of the Arts), the Creative Industries Observatory (CIO) is a leading contributor to academic research and analysis within the creative industries, and a source
Cardoso, Eva, Carnicero, Laura, Dempster, Anna, Joel, Sian, Liu, Kai, Mould, Oli, Pezzana, Silvio Pierluigi, Roodhouse, Simon   +7 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The State of the U.S. Workforce System: A Time for Incremental Realignment or Serious Reform? [PDF]

, 2012
A report from the John J. Heldrich Center for Workforce Development aims to start a dialogue about the U.S. workforce system, and what it would look like if it were built for today's economy and by using today's tools and processes.
Kathy Krepcio, Michele Martin
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source