Results 121 to 130 of about 3,987 (299)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Dans l’atelier de la chercheuse: Commenter étudier les violences contre les journalistes ?

Sur le Journalisme
FR. Cet article examine les choix méthodologiques posés dans le cadre d’une étude sur les violences et les expériences d’insécurité vécues par les journalistes francophones en Belgique. J’y explique comment mes postures d’ex-pigiste, mais aussi de femme,
Clémence Petit
doaj   +1 more source

Crime of Fraud in Vacancy of Freelance Job under the Guise of Like and Follow on Social Media

Dinasti International Journal of Education Management And Social Science
Social media as a means of communication and information exchange can now be utilized to create new jobs. However, the development of information and communication technology in the use of social media also has a negative impact, there is a group of people who are less responsible for its use, causing someone to suffer physical, psychological, and ...
Ayudhianti Pranchastika, Chazizah Gusnita   +1 more
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Vértigo Freelance: proyecto de campaña de comunicación gráfica sobre la incorporación laboral del diseñador gráfico [PDF]

, 2020
[ES] Desarrollo de una propuesta de campaña de comunicación sobre la incorporación de diseñadores gráficos noveles al mercado laboral freelance. La memoria documenta la conceptualización y creación del colectivo de diálogo Vértigo Freelance y su campaña ...
Abellán Martínez, Nuria
core  

Foreign correspondence from Sub-Saharan Africa: An evolving communicational paradigm shift / Corresponsales extranjeros en África Subsahariana: Un paradigma comunicativo en evolución

Index Comunicación, 2013
A sizable portion of our everyday knowledge about Sub-Saharan Africa comes from the work of international news reporters. Even though these news actors play a critical role in the communication of the distant Other, frequently criticized for its ...
Paulo Nuno Vicente, Universidade Nova de Lisboa   +1 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Media Cymru Freelance Focus: Innovation [PDF]

Executive SummaryThere are a multitude of interpretations of the concept of ‘innovation’ amongst screen sector freelancers. The concept is not always fully understood, but it is largely interpreted as both a product and a process.Screen sector ...
Davies, James, Jones, Bethan, Hurford, Richard   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source