Results 141 to 150 of about 3,987 (299)
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
AI-Powered Campaign Management: The Future of Freelance Media Buying
AI-Powered Campaign Management: The Future of Freelance Media Buying examines how artificial intelligence is transforming the way freelance media buyers manage digital advertising campaigns. It highlights how tools like Smart Bidding, automation scripts, and AI-driven creatives enable solo professionals to deliver agency-level results, scale operations
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2017 New media is a means of mass communication using digital technology such as internet. We can say that, New media most commonly refers to content available on-demand through the Internet, accessible on any digital device, usually containing interactive ...
Khanna, Manju; Assistant Professor, MBICEM +1 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Self-employment in Germany and the UK: Labor market regulation, risk-management and gender in comparative perspective [PDF]
Within the wide range of new forms of work self-employment seems to be a distinct feature concerning a growing part of the male and female labor force in industry and services in both Germany and the UK.
Gottschall, Karin, Kroos, Daniela
core
Sur le Journalisme, 2016 Cette contribution s’intéresse aux correspondants étrangers exerçant en France, assez peu étudiés. La réflexion proposée repose en grande partie sur une vingtaine d’entretiens avec les journalistes eux‑mêmes, travaillant à Paris pour différents pays et ...
Jérémie Nicey
doaj