Results 91 to 100 of about 15,270 (270)

Os media sociais nas estratégias de divulgação dos fotógrafos freelancers

, 2022
Social media today are as popular as traditional media. Their ease of use and accessibility have made them one of the preferred means for the dissemination of the most diverse situations. Social media marketing is currently part of the strategies of many companies.
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The price of freedom: the opportunities and constraints of freelance employment for older workers : a study of media professionals [PDF]

, 2002
The UK's population is ageing at a time when its oldest workers are leaving the labour market at progressively younger ages. This paradox - of declining economic activity rates among the 50 plus age group and rising longevity - has led to widespread concern over the social and economic consequences . Meanwhile, flexible work has grown in the UK economy
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

What about the teacher? Open educational resources et al

, 2008
As I began writing this proposal, serendipity struck in the form of two conversations about Open Educational Resources (OERs), one with a colleague in my own institution who has a respectable track record in innovative uses of educational technologies ...
Ferreira, Giselle
core  

SISTEM PENGUPAHAN PEKERJA FREELANCE PADA PERUSAHAAN INDUSTRI DAN PERDAGANGAN PT. HADENA INDONESIA DENGAN SISTEM MULTI LEVEL MARKETING DI KOTA BANDUNG DIKAITKAN DENGAN BUKU III KITAB UNDANGUNDANG HUKUM PERDATA [PDF]

, 2018
Salah satu usaha untuk memenuhi kebutuhan hidup manusia, seseorang dapat bekerja menjadi freelancer pada perusahaan dengan sistem Multi Level Marketing (MLM) industri dan perdagangan PT. Hadena Indonesia.
Deden Ahmad Rohendi, 131000256
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PERSONAL BRANDING OF FREELANCE MAKE UP ARTIST (MUA) IN PEKANBARU CITY ON INSTAGRAM SOCIAL MEDIA

Jurnal Netnografi Komunikasi
Searching for MUA services in the digital era is now easy, with many choices on social media such as Instagram, which allows searches based on domicile, price, characteristics or quality. This research aims to analyze the personal branding of freelance MUAs in Pekanbaru via Instagram, using Montoya's personal branding theory with eight indicators ...
null Suci Shinta Lestari, null Mutia Farina   +1 more
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source