Results 61 to 70 of about 336,194 (317)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Komunika, 2015 Dakwahtainment is a product of broadcasting media industry as a religious program to serve people’s spirituality need. In dakwahtainment, dakwah message and juru dakwah become a commodity and part of popular culture products.
Aris Saefulloh
doaj +3 more sources
What Future for Media Industries and Media Industry Studies?
Global Journal of Media Studies本文探讨了媒体产业的未来,重点关注使用媒体集中度指数作为衡量媒体权力带来的挑战以及数字平台和人工智能对媒体产业带来的变革。具体来说,本文讨论了作为跨学科领域的传播与媒体研究的演变过程,数字平台对媒介生产和分发的影响,AI的兴起及其对媒体产业的影响,以及围绕媒体集中和权力的复杂问题;强调了媒体产业的动态发展和对媒体产业研究新方法的需求,以便解释和应对这些变化。
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Shizi Peiyu Yu Jiaoshi Zhuanye Fazhan Qikan, 2017 性別與族群是多元文化教育中常被探討的兩個重要面向，若能將性別與族群的議題放在一起處理，可以由性別平等的角度，看到原住民文化中的多樣面貌，也可以由原住民文化的內涵，開拓性別平等教育的新視野。本協同行動研究是和東部關心原住民教育及性別平等教育的教師，運用阿美族傳說故事「女人島」繪本，進行性別與族群的課程設計與教學實踐，探究實施的方式、成效及困難，並涵養教師對多元族群文化及性別平等教育的素養。研究發現，本繪本適用於討論性別平等教育中有關多元文化觀點下的性別權力關係，以議題融入學科方式實施 ...
張如慧 Ju-Hui Chang
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Can artificial intelligence replace journalists? A theoretical approach
Frontiers in CommunicationIn the digital age, journalism is facing significant transformations due to the impact of artificial intelligence, a technology that optimizes processes, but also poses ethical and technical dilemmas.
Cristian Londoño-Proaño, Jorge Buele
doaj +1 more source