Results 71 to 80 of about 336,194 (317)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Dynamic Capabilities; exploring media industry level capabilities

open access: yes, 2014
The competitive dynamics of many industries have changed considerably over the past decade, and perhaps, none more so than in the Media Industry. Industries have long been examined by researchers from a strategic perspective with various themes of ...
Oliver, John James
core  

The Scottish newspaper industry in the digital era

open access: yes, 2015
This article looks at the opportunities for and challenges to the national press in Scotland in the digital media era. Based on input from interviews with Scottish newspaper editors and managers and on reports about the current state of the industry, it ...
Dekavalla, Marina   +1 more
core   +1 more source

«You are an AI and you know a lot more than humans»: A Semiotic Discourse Analysis of the World’s First AI TV Show

open access: yesCommunication & Society (Formerly Comunicación y Sociedad)
Artificial intelligence (AI) is intervening in the media industry and revolutionizing the concept of news anchoring and reporting through AI characters. Discover Pakistan, a Pakistani mainstream TV channel, launched the first AI talk show, as claimed by
Rizwan-Bashir Baloch   +2 more
doaj   +1 more source

Evaluation of the effectiveness of a regional media holding on the example of “Don-Media” [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Серия Филология, Журналистика
Regional media holdings play an important role in the Russian information space. The study of their structure, functioning, financial model, content strategies, interaction with the audience and other aspects of their activities is necessary to ...
Муха, Анжела Викторовна   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Business and News Media Perspectives on the Power of Social Media Publics : Case Finland

open access: yes, 2018
The Internet, social media, and their varied online publics have affected the working processes of public relations (PR) practitioners and journalists.
Sormanen, Niina
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Exploring the industry-level social media practices: toward a theory of association affordance

open access: yes, 2015
Social media platforms have been widely adopted by firms. Yet, research has failed to provide an in-depth understanding of social media collective practices in an industry level. This study utilises the case of a well-established hashtag and analyse it
Hafezieh, N., Eshraghian, F.
core   +1 more source

The Media Industry’s Structural Transformation in Capitalism and the Role of the State: Media Economics in the Age of Digital Communications

open access: yestripleC: Communication, Capitalism & Critique, 2015
: This paper discusses how the capitalist media industry has been structurally transformed in the age of digital communications. It takes an approach that is grounded in the Marxian critique of the political economy of the media. It draws a distinction
Manfred Knoche
doaj   +1 more source

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