Results 81 to 90 of about 2,227,215 (313)

Active regulation of the epidermal calcium profile [PDF]

open access: yes, 2012
A distinct calcium profile is strongly implicated in regulating the multi-layered structure of the epidermis. However, the mechanisms that govern the regulation of this calcium profile are currently unclear.
Adams, Matthew   +2 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

POLITICAL JOURNALISM: Fiji media regulation: Emerging from ‘worst of times’ to ‘best of times’?

open access: yesPacific Journalism Review, 2015
A tragic result of the repressive media environment in Fiji has been a huge brain drain within the industry. Many of the best and experienced media workers have left or been forced out.
Ricardo Morris
doaj   +1 more source

Regulasi Emosi Pada Pengguna Media Sosial [PDF]

open access: yes, 2018
Social media is a social interaction between individual on sharing and exchange information. The phenomena associated with social media are increasingly emerging along with the intense use of social media.
, Dr. Wiwien Dinar Pratisti, M.Si, Psi   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Mergers and acquisitions in TV production, aggregation and distribution: challenges for competition, industrial and media policy [PDF]

open access: yes, 2015
This paper focuses on the recent wave of M&A activity, both vertical and horizontal in TV production, aggregation and distribution industries, and discusses the implications of M&A activity for competition, industrial and media policymaking. Moreover, it
Donders, Karen, Evens, Tom
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Regulating advertising in the presence of public service broadcasting [PDF]

open access: yes
Television advertising levels in Europe are regulated according to the Audiovisual Service Media Directive where member states of the European Union usually impose stricter regulation on their Public Service Broadcasting (PSB) channels. The present model
Stühmeier, Torben, Wenzel, Tobias
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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