Results 91 to 100 of about 30,781,799 (291)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Socio-Political Telegram Channels Reporter and Lentach as New Media

Виртуальная коммуникация и социальные сети, 2023
The article describes new digital mass media that engage users in content creation and distribution. The research covered the content published in Telegram channels Reporter and Lentach between November 29 and December 12, 2021.
Valentin E. Solomin, Nikita A. Karev
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Chaos media: A sonic economy of digital space

, 2015
The contemporary media landscape might be described in simple terms as a digital terrain where real and virtual worlds collide. Stephen Kennedy investigates the concept of our digital space leading up to the digital turn of the 1990s to fully understand ...
Kennedy, Stephen
core   +2 more sources

A global portrait of expressed mental health signals towards COVID-19 in social media space. [PDF]

Int J Appl Earth Obs Geoinf, 2023
Wang S, Huang X, Hu T, She B, Zhang M, Wang R, Gruebner O, Imran M, Corcoran J, Liu Y, Bao S.   +10 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

LINGUISTIC FEATURES OF NATO’S MEDIA IMAGE (THE CASE STUDY OF BRITISH ONLINE PUBLICATIONS)

Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2014
The paper investigates linguistic specific means of NATO's image making in online British leading newspapers. The case study involves news reports and analytical articles that represent explicit and implicit evaluation of the North Atlantic Treaty ...
Valuyskaya Olga Ruslanovna
doaj   +1 more source

The Soviet Epoch in Polycode Precedent Media Reflection, or From Each According to His Ability, to Each According to His Need [PDF]

Актуальные проблемы филологии и педагогической лингвистики
The article studies linguasemiotic features and functional meanings of precedent phenomena (PP) of the Soviet past through the prism of polycode representation in modern discursive space.
Tatiana V. Marchenko
doaj   +1 more source