Results 161 to 170 of about 50,670,518 (386)

Book review: media regulation: governance and the interests of citizens and consumers by Peter Lunt and Sonia Livingstone [PDF]

open access: yes, 2012
In Media Regulation, Peter Lunt and Sonia Livingstone examine the challenges of regulation in the global mediated sphere. The book explores the way that regulation affects the relations between government, the media and communications market, civil ...
Iosifidis, Petros
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Media studies to enhance the production of verticillins facilitated by in situ chemical analysis. [PDF]

open access: yesJ Ind Microbiol Biotechnol, 2018
Amrine CSM   +4 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

#any use? What do we know about how teachers and doctors learn through social media use? [PDF]

open access: yes, 2017
This scoping literature review describes the landscape of recent publications (2007-2016) about how teachers and doctors learn through social media to identify whether learning was being considered and, if so, how evidence was collected (N=162).
Bird, Terese, Fox, Alison
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Sports Journalists as Agents of Change in Nordic Countries

open access: yesMedia and Communication
Sports Journalists as Agents of Change: Shifting Political Goalposts in Nordic Countries identifies and describes changes prevalent in political narratives of sports journalism. Although tensions between professional autonomy and commercial influences in
Anders Graver Knudsen   +2 more
doaj   +1 more source

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