Results 51 to 60 of about 57,844,370 (303)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Feedback on the proposal for a regulation establishing a common framework for media services in the internal market (European Media Freedom Act) and amending Directive 2010/13/EU [PDF]

, 2023
With this contribution, the Centre for Media Pluralism and Media Freedom (CMPF) at the European University Institute offers a feedback to some aspects of the Proposal for a Regulation of the European Parliament and the Council establishing a common ...
Centre for Media Pluralism and Media Freedom
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Periphrases of St. Petersburg in Contemporary Media Discourse: A Pragmatic Perspective

Научный диалог
This article examines the distinctive features of periphrastic nominations of St. Petersburg in modern media texts, as represented in the newspaper corpus of the Russian National Corpus.
E. A. Bespalova
doaj   +1 more source

Income, Nationality and Subjectivity in Media Text

Journal of Linguistics/Jazykovedný casopis, 2021
Abstract This article takes a bird’s eye view of how positive or negative sentiments in the news press about countries and nationality nouns seem to reflect the country’s general income groups. The study focuses on the four income groups classified by the World Bank and their co-occurrence with positively and negatively classified ...
openaire   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Engineering Media Texts with High Dialogic Potential

Научный диалог
This article focuses on the engineering of media texts characterized by a high level of public engagement, wherein the dialogic potential of media communications is fully realized.
E. S. Radiontseva
doaj   +1 more source

Winged units of literary origin in Orthodox media texts

Opera slavica, 2020
The article is devoted to winged units dating back to Russian literature and used in the texts of modern Orthodox media discourse. Remaining one of the main sources of the winged units, literature contends for primacy with synthetic genres (cinema ...
Svetlana Viktorovna Duduškina, Ol'ga Valentinovna Lomakina, Aleksandra Stefanovna Makarova   +2 more
doaj   +1 more source

Civil society in Yemen in the era of network communications and new media: on the civil activism issue

Неофилология, 2022
The purpose of the study is to analyze the specifics of the Yemen “new media” functioning associated with the use of the Internet and digital technologies, paying special attention to the functioning of citizen journalism. The problems of studying Arabic
Abdulrahman Hassan Abdulrahman Ba Haron
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source