Results 41 to 50 of about 2,509,838 (314)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The parental media mediation context of young children’s media use
, 2017 Researchers widely agree that how children spend their time is an important predictor of the development of their skills, relationships, attitudes, and behavior patterns.
Barr, R. +2 more
core +1 more source
Frontiers in Public Health, 2022 BackgroundThe media is playing an increasingly important role in the lives of older adults. Exploring health inequalities in older adults is essential for achieving healthy aging.
Han Wang +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Social Media in Educational Practice: Faculty Present and Future Use of Social Media in Teaching [PDF]
, 2017 This paper presents results from a questionnaire (n=333) designed to gain an understanding of instructor motivations and experience with social media use in educational practice.
Esteve Del Valle, Marc; id_orcid +10 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2007 This article examines New Zealand print media representations of assisted reproductive and related biogenetic technologies, conceptualized as the products of a concordance of interest between media workers and reproductive specialists, biogenetic ...
Michelle, Carolyn
core +1 more source
From the Ethical Use of the Media to a 'useful' Media Ethics
The International Review of Information Ethics, 2004 Without knowing the rules of the game in a specific area qualified ethical decisions within are simply not possible. Therefore, a fundamental understanding of the phenomenon 'media' is a prerequisite for the ‘usablity’ of any media ethics. This understanding of the very basis of media is introduced by the notion of space: media is the space where the ...
openaire +2 more sources