Results 101 to 110 of about 3,476,975 (297)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A note on Condorcet consistency and the median voter [PDF]

We discuss to which extent the median voter theorem extends to the domain of single-peaked preferences on median spaces. After observing that on this domain a Condorcet winner need not exist, we show that if a Condorcet winner does exist, then it ...
Buechel, Berno
core  

Protecting Critical Assets: The r-interdiction Median Problem with Fortification [PDF]

, 2005
Many systems contain bottlenecks, critical linkages, and key facilities. Such components, when lost due to a man-made or natural disaster, may imperil a system in performing its intended function.
Church, Richard L., Scaparra, Maria Paola   +1 more
core  

Median-joining network of Pvama1 between three geographically diverse populations of India.

, 2021
Pvama1 ectodomain sequences from three geographical diverse malaria-endemic regions of India were used to create a median-joining network. This network represents the mutational paths connecting Pvama1 haplotypes that may explain the observed sequence ...
Veena Pande (3108393), Jane M. Carlton (9091536), Prashant K. Mallick (11250800), Sonal Kale (11250797), Om P. Singh (10968612)   +4 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Intermittent Hypoxic–Hyperoxic Training During Inpatient Rehabilitation Improves Exercise Capacity and Functional Outcome in Patients With Long Covid: Results of a Controlled Clinical Pilot Trial

Journal of Cachexia, Sarcopenia and Muscle
Introduction Long COVID‐19 illness is a severely disabling disease with shortness of breath, weakness and fatigue as leading symptoms, resulting in poor quality of life and substantial delay in return to work.
Wolfram Doehner, Azadeh Fischer, Banafsheh Alimi, Jasmin Muhar, Jochen Springer, Christoph Altmann, Per Otto Schueller   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Median-joining cytochrome c oxidase subunit I (COI) haplotype network.

, 2016
Median vectors are indicated by small red circles. High-frequency haplotypes are labeled as well as the number of mutations for each branch (if not 1).
Derek J. Taylor (130599), Dmitry P. Karabanov (3074235), Eugeniya I. Bekker (3074238), Alexey A. Kotov (659809), Tatiana V. Neretina (642007)   +4 more
core   +1 more source

Mathematical Statistics in the Geology [PDF]

Acta Montanistica Slovaca, 1999
During the last period is modern geology oriented toward intensive utilisation of mathematical methods. Utilisation of these methods was conditioned by complicated structure of geological bodies, which resulted from interaction of a couple of factors. In
Blišťan Peter
doaj