Results 171 to 180 of about 207,808 (198)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
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Journal of the American Statistical Association, 1967
Abstract Let X 1, …, Xn be identically distributed according to a symmetric distribution F (satisfying suitable regularity conditions). An approximation to the variance of the median is computed up to terms of order 1/n 2 and a corresponding approximation to the efficiency of relative to the average up to terms of order 1/n.
J. L. Hodges, E. L. Lehmann
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Abstract Let X 1, …, Xn be identically distributed according to a symmetric distribution F (satisfying suitable regularity conditions). An approximation to the variance of the median is computed up to terms of order 1/n 2 and a corresponding approximation to the efficiency of relative to the average up to terms of order 1/n.
J. L. Hodges, E. L. Lehmann
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SIAM Journal on Computing, 1999
Summary: Improving a long-standing result of \textit{A. Schönhage, M. Paterson}, and \textit{N. Pippenger} [J. Comput. Syst. Sci. 13, 184-199 (1976; Zbl 0333.68033)] we show that the median of a set containing \(n\) elements can always be found using at most \(c \cdot n\) comparisons, where ...
Dorit Dor, Uri Zwick
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Summary: Improving a long-standing result of \textit{A. Schönhage, M. Paterson}, and \textit{N. Pippenger} [J. Comput. Syst. Sci. 13, 184-199 (1976; Zbl 0333.68033)] we show that the median of a set containing \(n\) elements can always be found using at most \(c \cdot n\) comparisons, where ...
Dorit Dor, Uri Zwick
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Journal of the Operational Research Society, 1984
The classical p-median problem is discussed, together with methods for its solution. The multi-median problem, a generalization of the p-median problem in which more than one type of facility is allowed, is introduced and methods of solution developed. Numerical results are presented.
Boffey, T. B., Karkazis, J.
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The classical p-median problem is discussed, together with methods for its solution. The multi-median problem, a generalization of the p-median problem in which more than one type of facility is allowed, is introduced and methods of solution developed. Numerical results are presented.
Boffey, T. B., Karkazis, J.
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Median power and median correlation theory
IEEE Transactions on Signal Processing, 2002We show that the maximum likelihood (ML) estimate of location under the Laplacian model, which forms the basis for weighted median filters, can be generalized to correlation estimates based on weighted medians. Much like linear sample correlations, the resultant median correlation estimates have a surprisingly simple structure.
Gonzalo R. Arce, Yinbo Li
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