Results 81 to 90 of about 2,208,107 (416)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Ultrasound assessment of the median nerve: a biomarker that can help in setting a treat to target approach tailored for carpal tunnel syndrome patients

SpringerPlus, 2015
Ultrasonography (US) is a valuable tool for confirming the diagnosis of carpal tunnel syndrome (CTS) as it enables the detection of changes in the median nerve shape and rule out anatomic variants as well as space-occupying lesions such as ganglion cysts
Y. El Miedany, M. El Gaafary, S. Youssef, I. Ahmed, A. Nasr   +4 more
semanticscholar   +1 more source

Median nerve conduction impairment in patients with diabetes and its impact on patients’ perception of health condition: a quantitative study [PDF]

, 2013
INTRODUCTION: Impaired mobility and compromised manual dexterity leading to difficulties with the activities of daily living (ADL) are an inherent part of the clinical picture in diabetes.
Barbara Polityńska, Elżbieta Krajewska-Kułak, Jan Kochanowicz, Jolanta Lewko, Maria Górska, Wiesław Zarzycki, Zenon Mariak   +6 more
core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Effect of Wrist Angle on Median Nerve Appearance at the Proximal Carpal Tunnel

PLoS ONE, 2015
This study investigated the effects of wrist angle, sex, and handedness on the changes in the median nerve cross-sectional area (MNCSA) and median nerve diameters, namely longitudinal diameter (D1) and vertical diameter (D2).
P. Loh, S. Muraki
semanticscholar   +1 more source

Patient-Reported Disability Measures Do Not Correlate with Electrodiagnostic Severity in Carpal Tunnel Syndrome. [PDF]

, 2017
BACKGROUND: Electrophysiologic studies including electromyography and nerve conduction studies play a role in the evaluation of carpal tunnel syndrome (CTS), despite evidence that these studies do not correlate with CTS-specific symptom scores.
Atroshi, Bakhsh, Bessette, Chan, Changulani, Cohen, Das De, de la Llave-Rincón, de-la-Llave-Rincon, Graham, Itsubo, Jablecki, Jordan, Kimura, Kronlage, Levine, Makanji, Niekel, Nunez, Robinson, Sandin, Sucher, Ware, Watson, Werner, Wilder-Smith   +25 more
core   +2 more sources

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Discrimination Among Multiple Cutaneous and Proprioceptive Hand Percepts Evoked by Nerve Stimulation with Utah Slanted Electrode Arrays in Human Amputees [PDF]

arXiv, 2020
Objective: This paper aims to demonstrate functional discriminability among restored hand sensations with different locations, qualities, and intensities that are evoked by microelectrode stimulation of residual afferent fibers in human amputees. Methods: We implanted a Utah Slanted Electrode Array (USEA) in the median and ulnar residual arm nerves of ...
arxiv  

Generalized nerves of monads [PDF]

arXiv, 2022
One interpretation of the Kleisli construction (given by Miranda and related to work of Par\'e) is as a nerve sending a monad $P$ to the Kleisli double category of $P$. In this paper we find more general nerve constructions on the 2-categories of monads, which also give fully faithful nerve 2-functors $\mathbf{Mnd}\left(\mathcal{K}\right)\to\mathbf{Dbl}
arxiv  

Is the difference between median sensory and ulnar motor latencies better than combined sensory index in carpal tunnel syndrome diagnosis? [PDF]

, 2016
Objectives: This study aims to compare the sensitivity and specificity of median sensory nerve/ulnar motor nerve latency difference (MSUMLD) as a new method with combined sensory index (CSI) for accurate diagnosis of carpal tunnel syndrome.
Azadeh, Asma., Bemana, Ghahraman., Emad, Mohammadreza., Jahani, Navid.   +3 more
core   +1 more source