Results 61 to 70 of about 288,400 (308)

First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants

Clinical Pharmacology &Therapeutics, EarlyView.
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr, Faiza Rharbaoui, Dietmar Weitz, Johann Gassenhuber, Markus Rehberg, Markus Kohlmann, Fabienne Schumacher, Amel Lahmar, Andreas Kovar, Laurent Perrin, Frank‐Dietrich Wagner, Maria Wiekowski, Mai Anh Nguyen   +12 more
wiley   +1 more source

A Comparative Study on the Diagnosis and Staging of Lung Cancer 
between Mediastinoscopy and EBUS-TBNA

Chinese Journal of Lung Cancer, 2013
Background and objective Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been gradually universal application, but its value in the preoperative staging of lung cancer and mediastinal mass biopsy remains to be explored ...
Liang ZHANG, Feng MAO, Minghui CAI, Yang SHEN-TU   +3 more
doaj   +1 more source

Primary mediastinal seminoma with florid follicular lymphoid hyperplasia: a case report and review of the literature

Diagnostic Pathology, 2021
Background First described in 1955 Primary mediastinal seminomas are rare. Only 1–4% of mediastinal tumours are germ cell tumors; majority of which are teratomas. They typically present in men aged between 20 and 40 years.
Charlotte Holmes, Peh Sun Loo, Sion Barnard   +2 more
doaj   +1 more source

Cytologic Diagnoses of Lung Adenocarcinoma With Concomitant Metastasis From a Different Primary: A Case Series

Diagnostic Cytopathology, EarlyView.
ABSTRACT Lung adenocarcinoma is a common malignancy that can metastasize. The lung is also a common site for metastasis from other sites. Prompt and accurate diagnosis is critical for patient management. The diagnosis of lung adenocarcinoma can be occasionally challenging due to overlapping clinical and pathological features with adenocarcinomas from ...
Robert Pei, Shane M. Woods, Brant G. Wang   +2 more
wiley   +1 more source

The association between additional radiotherapy after systemic chemotherapy and the prognosis of stage FIGO 2018 IVB cervical cancer

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Systemic platinum‐based chemotherapy is the first‐line treatment of choice for metastatic cervical cancer. While subsequent radiotherapy after primary chemotherapy is a potential option, its benefit remains unclear. This multicenter retrospective study aimed to evaluate whether post‐chemotherapy radiotherapy improves the prognosis of
Ai Miyoshi, Fumiaki Isohashi, Makoto Fujii, Tadashi Iwamiya, Masahiko Takemura, Yoshikazu Nagase, Takeshi Yokoi, Emi Yoshioka, Kimihiko Ito, Eri Yamabe, Kanji Masuhara, Tomoko Tsujie, Tadashi Kimura, Michiko Kodama   +13 more
wiley   +1 more source

Mediastinal and Retropharyngeal Abscesses in a Neonate

Pediatrics and Neonatology, 2011
Mediastinal abscess following retropharyngeal abscess is a rare entity. We report the first neonate presenting with a large mediastinal abscess as a complication of a retropharyngeal abscess.
Chien-Han Chen, Chao-Jan Wang, Reyin Lien, Yi-Hung Chou, Chien-Chih Chang, Ming-Chou Chiang   +5 more
doaj   +1 more source

Sarcoid‐Like Reaction (SLR) Associated With Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma

IJU Case Reports, EarlyView.
ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) are useful in the treatment of metastatic renal cell carcinoma. ICIs have been associated with a variety of immune‐related adverse events (irAEs), one of which is a sarcoid‐like reaction (SLR). SLR is often difficult to distinguish from cancer progression.
Kanta Fukushima, Sota Mizukoshi, Tomohiro Ino, Takuya Ishida, Yumika Ito, Akira Okimura, Munehide Nakatsugawa, Takeshi Hashimoto   +7 more
wiley   +1 more source

Clinical Assessment of the Drug–Drug Interaction Potential of Omaveloxolone in Healthy Adult Participants

The Journal of Clinical Pharmacology, EarlyView.
Abstract Omaveloxolone is approved in the United States and the European Union for the treatment of patients with Friedreich ataxia aged ≥16 years. It is mainly metabolized by cytochrome P450 (CYP) 3A4 in vitro. Two drug–drug interaction studies (NCT04008186 and NCT05909644) were performed to evaluate (1) the effect of drug‐metabolizing enzymes (DMEs ...
Hamim Zahir, Masako Murai, Lucy Wu, Michelle Valentine, Scott Hynes   +4 more
wiley   +1 more source

Fetal Cardiovascular Magnetic Resonance: History, Current Status, and Future Directions

Journal of Magnetic Resonance Imaging, EarlyView.
Fetal cardiovascular magnetic resonance imaging (MRI) has emerged as a complementary modality for prenatal imaging in suspected congenital heart disease. Ongoing technical improvements extend the potential clinical value of fetal cardiovascular MRI.
Dominika Suchá, Anneloes E. Bohte, Pim van Ooij, Tim Leiner, Eric M. Schrauben, Heynric B. Grotenhuis   +5 more
wiley   +1 more source

Masa mediastínica de origen desconocido

Cirugía Cardiovascular, 2018
Resumen: Presentamos un raro caso de un paciente al que se le descubre de manera casual una masa en mediastino anterior. La masa comprimía las cavidades derechas del corazón.
José Manuel Vignau Cano, Carmen Carmona Vela, Alfredo López González   +2 more
doaj