Results 121 to 130 of about 50,811 (294)

When to consider an inborn error of immunity: clues for physicians

Internal Medicine Journal, EarlyView.
Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley   +1 more source

Mediastinal silicon-induced lymphadenopathy mimicking “N3” disease in resectable lung cancer

, 2018
Silicone implant leakage can be associated with mediastinal silicon-induced lymphadenitis, representing a diagnostic challenge in case of previous history of malignant neoplasms or synchronous cancer. Silicone lymphadenopathy is due to the deposition, in
A. Mariolo, F. Petrella, L. Spaggiari, L. Girelli, E. Prisciandaro, S. Pirola   +5 more
core   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Impaired hematopoiesis affects apheresis and CAR T‐cell product composition and treatment response

Transfusion, EarlyView.
Abstract Background Chimeric antigen receptor (CAR) T‐cell therapy has transformed the treatment of hematologic malignancies, but its success depends on obtaining sufficient CD3+ T‐cell yields during leukapheresis. This can be difficult in heavily pretreated patients, who often show leukopenia and reduced T‐cell fitness.
Hanna Kuhn, Felix Korell, Angela Hückelhoven‐Krauss, Brigitte Neuber, Miriam Stenzinger, Anita Ludwig‐Husemann, Maria‐Luisa Schubert, Patrick Derigs, Kiavasch Farid, Tim Sauer, Sandra Sauer, Carsten Müller‐Tidow, Peter Dreger, Michael Schmitt, Anita Schmitt   +14 more
wiley   +1 more source

Case Report of a Giant Mediastinal Neurofibroma Misdiagnosed as Massive Pleural Effusion

Clinical Case Reports
Mediastinal neurogenic tumors are benign neoplasms commonly found along nerves in the posterior mediastinum, with rare malignant transformation. We report a case of a 36‐year‐old woman admitted to the respiratory department with complaints of chest ...
Hongqiang Chen, DanYi Lin, Zhizhong Zhou
doaj   +1 more source

Assesment of Mediastinoscopy Surgery Results in Patients with Mediastinal Tumor Reffered to Besat Hospital in Hamadan City from 2014 to 2019

پزشکی بالینی ابن سینا, 2020
Background and Objective: One of the important steps in continuing the treatment of patients with mediastinal masses is definitive diagnosis using tissue sampling of the lesion within the mediastinum.
Hamidreza Khorshidi, Masoud Tarbiat, Abbas Moradi, Babak Karimi   +3 more
doaj  

Effect of Interval Between Neoadjuvant Immunochemotherapy and Radical Resection of Non‐Small Cell Lung Cancer: A Multicenter, Retrospective Cohort Study

International Journal of Cancer, Volume 159, Issue 4, Page 985-996, 15 August 2026.
The optimal timing of surgery after neoadjuvant immunochemotherapy (NICT) for locally advanced non‐small cell lung cancer (NSCLC) remains unclear. In this retrospective investigation, the impact of time interval on outcome was assessed among NSCLC patients who completed NICT before undergoing radical resection.
Jiayi Wang, Pingping Song, Yong Ge, Haitang Yang, Shuyuan Li, Ran Ma, Tianyue Ma, Shoujie Feng, Cheng Zhang, Teng Sun, Feng Yao, Jun Yi, Hao Zhang   +12 more
wiley   +1 more source

Extramedullary mediastinal plasmacytoma. Report of one case [PDF]

, 2017
Solitary extramedullary plasmacytomas represent 3% of plasma cell neoplasms. Their most common locations are the upper gastrointestinal and respiratory tract. We report a 70-year-old male presenting with progressive dyspnea and cough.
Quilodrán, Javier A., Peña, Camila, Valladares, Ximena   +2 more
core  

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Diagnostic Yield of CE-EBUS in Mediastinal and Hilar Lymphadenopathy: A Preliminary Study

Background/Objectives: Contrast-enhanced endobronchial ultrasound (CE-EBUS) is a minimally invasive technique that combines traditional endobronchial ultrasound (EBUS) with a contrast agent (sulfur hexafluoride), enhancing the visualization of blood flow
Antonio Sarubbi, Filippo Longo, Pierfilippo Crucitti, Ilaria Suriano, Luca Frasca, Giovanni Tacchi   +5 more
core   +1 more source