Results 101 to 110 of about 193,741 (293)

Ibrutinib and standard immunochemotherapy in younger, high‐risk patients with diffuse large B‐cell lymphoma: A phase II study of GLA

British Journal of Haematology, EarlyView.
Summary Younger patients with high‐risk diffuse large B‐cell lymphoma (DLBCL) frequently have unfavourable outcomes. We conducted a prospective phase II study evaluating ibrutinib plus rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R‐CHOEP+I) in patients aged 18–60 years with DLBCL and age‐adjusted international prognostic index ≥2.
Evgenii Shumilov, Marita Ziepert, Birte Friedrichs, Susanne Ghandili, Kai Wille, Bertram Glass, Maike Nickelsen, Peter Borchmann, Andreas Viardot, Andrea Kerkhoff, Philipp Berning, Sebastian Böttcher, Stefan Wirths, Tobias Kewitz, Mathias Hänel, Judith Dierlamm, Andreas Rosenwald, Bettina Altmann, Georg Lenz, Norbert Schmitz   +19 more
wiley   +1 more source

Predicting Role of Preoperative Computed Tomography Features on Invasiveness of Thymic Neoplasms

, 2020
Objective: The anterior mediastinal masses are composed of neoplasms from many different groups, thymic epithelial tumors being the most common type. Histologic subtype, tumor stage and completeness of resection are considered to be the most important ...
UYSAL, Serkan, ARIYÜREK, Orhan Macit, DİKMEN, Erkan, DEMİRCİN, Metin, TAYDAS, Onur, YILMAZ, MUSTAFA, KUMBASAR, Ulas, DOGAN, Riza   +7 more
core  

Whole‐genome and transcriptome analysis in relapsed/refractory non‐Hodgkin lymphoma: Results from a multicentre precision oncology cohort

British Journal of Haematology, EarlyView.
Summary Comprehensive genome and transcriptome profiling can inform the diagnosis, prognosis and management of relapsed/refractory (R/R) solid malignancies, yet its integration into clinical care has lagged despite strong biological rationale. We evaluated the clinical utility of whole genome and transcriptome analysis (WGTA) in 65 patients (37 ...
Kathleen Wee, Eric J. Zhao, Cassidy Clemente‐Jones, Rebecca J. Deyell, Shahrad R. Rassekh, Anita Villani, Rosemarie Venier, Daniel Sinnett, Sylvie Langlois, Thai Hoa Tran, Thomas Sontag, Stephanie Grover, Scott Davidson, Nisha Kanwar, Winnie Lo, Erin Pleasance, Laura Williamson, Yaoqing Shen, Alina S. Gerrie, Kerry J. Savage, Laurie H. Sehn, Christopher P. Venner, Marco A. Marra, Janessa Laskin, Diego Villa   +24 more
wiley   +1 more source

Navigating the Diagnostic Gray Zone: A Case Series on Mediastinal Gray Zone Lymphomas

Current Medical Issues
Gray zone lymphomas (GZLs) are rare mature B-cell neoplasms characterized by overlapping morphologic and immunophenotypic features of classical Hodgkin lymphoma (CHL) and diffuse large B-cell lymphoma, particularly primary mediastinal B-cell lymphoma ...
P. Shiny Latha, R. Premadevi, P. Kanmani, P. Rajkumar   +3 more
doaj   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source

Cardiac injury as late toxicity of mediastinal radiation therapy for Hodgkin's disease patients

Haematologica, 1996
BACKGROUND. During the last 20 years Hodgkin's disease (HD) has become one of the most curable neoplasms; in fact, more than 75-80% of patients are expected to achieve long-term relapse-free survival with appropriate therapy.
PL Zinzani, F Gherlinzoni, G Piovaccari, G Frezza, M Bendandi, RM Ferretti, E Barbieri, M Fiacchini, L Babini, B Magnani, S Tura   +10 more
doaj  

A giant anterior mediastinal thymolipoma mimicking dextrocardia with cardiomegaly: a case report and review of literature

BMC Pulmonary Medicine
Background Thymolipoma is a rare benign anterior mediastinal tumour composed of thymic and adipose tissue, accounting for only 2–9% of thymic neoplasms (Mohamud et al., J Surg Case Rep 2020,2020; Shrivastava and Ntiamoah, Radiol Case Rep 15:1538-1540 ...
Niroshan Lokunarangoda, Dhammike Rasnayake, Miyuru Dulanjana, Duminda Samarasinghe, Ushani Wariyapperuma   +4 more
doaj   +1 more source

Efficacy and Safety of DVDMS‐Photodynamic Therapy for Dysphagia in Advanced Esophageal Cancer: A Phase II Clinical Trial

Cancer Science, EarlyView.
In this single‐arm Phase II trial, cosiporfin sodium‐mediated photodynamic therapy demonstrated efficacy in alleviating dysphagia and improving quality of life for patients with advanced esophageal cancer, with rapid onset, sustained efficacy, and good tolerability.
Jun Zhou, Shegan Gao, Jiajia Yuan, Hao Chen, Yongqian Shu, Huizhen Fan, Yanshuo Cao, Tanyou Shan, Caihong Dong, Hao Zhang, Qingting Song, Baobao Xin, Hao Zhang, Zhihao Lu, Lin Shen   +14 more
wiley   +1 more source

Pulmonary Carcinoid Presenting with Acute Pericarditis and Cardiac Tamponade: A Rare Case Report

Journal of Radiation and Cancer Research
Pulmonary neuroendocrine neoplasms are rare malignancies, with typical carcinoid (TC) tumors accounting for 2% of lung cancers. Carcinoid heart disease is uncommon, and pericardial involvement without valvular heart disease is exceedingly rare.
Prabhjeet Singh Bathla, Nikhil Thakur, T. V. S. V. G. K. Tilak, Neelam Sharma   +3 more
doaj   +1 more source