Results 81 to 90 of about 193,741 (293)

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Primary leiomyosarcoma originating from the azygos vein misdiagnosed as tracheal tumor: a case report and literature review

Frontiers in Oncology
Leiomyosarcomas are uncommon mesenchymal neoplasms. Primary mediastinal leiomyosarcomas are even rarer with only a limited number of cases reported. Given the high potential for recurrence and metastasis, accurate and timely diagnosis become extremely ...
Long-fei Zhu, Yu-jun Wang, Chun-jian Zuo, Yuan-lin Deng, Bin Jiang   +4 more
doaj   +1 more source

Uncommon Presentations of Pancreatic Neoplasms, Rare Neoplasms, and Peripancreatic Masses

, 2022
Pancreatic masses with atypical radiological appearance are frequently encountered. Atypical presentation of common pancreatic tumor is also possible.
Antonia Olivieri, Roberto Calbi, Paola Capelli, Angela Calabrese, Paolo Tinazzi Martini, Nicolò Cardobi, Mirko D’Onofrio, Riccardo De Robertis, Luca Geraci   +8 more
core   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Tuberculosis presenting as Anterior Mediastinal Mass: A Case Report

Journal of Nepal Medical Association
The mediastinum, located between the pleural sacs, has three compartments. The anterior mediastinum spans anteriorly from the sternum to the pericardium and brachiocephalic vessels posteriorly.
Simran Pradhan, Image Khadka
doaj   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

A case of emergent operation for a life-threatening infectious mediastinal cyst [PDF]

, 2019
PURPOSE: Congenital mediastinal cysts are an uncommon but important diagnostic group. Most of thesecysts are benign and asymptomatic in adults. However, some of them are clinically problematic due tothe compression of neighboring organs, infection, or ...
Taniguchi, Daisuke, Nagayasu, Takeshi, Fukuoka, Junya, Watanabe, Hironosuke, Miyazaki, Takuro, Zaizen, Yoshiaki, Matsumoto, Keitaro, Tsuchiya, Tomoshi, Hatachi, Go, Tomoshige, Koichi, Doi, Ryoichiro   +10 more
core   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

PCM1-JAK2-fusion : a potential treatment target in myelodysplastic-myeloproliferative and other hemato-lymphoid neoplasms

, 2010
Activating mutations of the JAK2 gene are of tumorigenic significance in myeloproliferative neoplasms. Translocations involving the JAK2 locus are of oncogenic importance in acute leukemias, myelodysplastic/myeloproliferative diseases and T-cell ...
Reiter, Andreas, Sylvia Hoeller, Christoph Walz, Tzankov, Alexandar, Andreas Reiter, Alexandar Tzankov, Walz, Christoph, Dirnhofer, Stephan, Stephan Dirnhofer, Hoeller, Sylvia, Walz C, Dirnhofer S, Tzankov A, Reiter A, Hoeller S   +14 more
core   +1 more source

Neoplastic Risk in Patients With Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Besides gonadal involvement (hypogonadism, male factor infertility, and testicular hypotrophy), patients with Klinefelter syndrome (KS) may suffer from several extra‐gonadic complications, including neoplastic events. Objective The aim of this review is to summarize all major clinical evidence dealing with the association between KS
Andrea Graziani, Giuseppe Grande, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +4 more
wiley   +1 more source