Results 31 to 40 of about 193,741 (293)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Flow Cytometry-Guided Diagnosis of Cortical T-Lymphoblastic Lymphoma Presenting With a Massive Mediastinal Mass and Borderline Bone Marrow Involvement. [PDF]

J Clin Lab Anal
ABSTRACT Background T‐cell lymphoblastic lymphoma (T‐LBL) and T‐cell acute lymphoblastic leukemia (T‐ALL) are considered a single biological entity, distinguished primarily by the extent of bone marrow infiltration. This distinction becomes diagnostically challenging in patients with borderline marrow blast counts and predominantly extramedullary ...
Glait-Santar C, Moshe Y, Ayelet IA, Katz BZ.   +3 more
europepmc   +2 more sources

Case Report: Multidisciplinary Approach for a Rare Case of Thymic Vascular Malformation

Frontiers in Surgery, 2021
We report the rare case of a 2.5 cm in size mass diagnostic for residual thymus associated with venous vascular malformation (ISSVA classification, 2008) in a 58 years old man.
Federico Raveglia, Laura Moneghini, Maurizio Cariati, Alessandro Baisi, Angelo Guttadauro, Ugo Cioffi, Marco Scarci   +6 more
doaj   +1 more source

The Diagnostic Utility of Real-Time EBUS-TBNA for Hilar and Mediastinal Lymph Nodes in Conventional TBNA Negative Patients

, 2014
Background: There are many causes of mediastinal and hilar lymphadenopathy, such as neoplasms, granulomatous diseases, infections and reactive hyperplasia. Nowadays, the popularity of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-
CETINKAYA, Erdogan, OZGUL, Guler, OZGUL, M. Akif, CAM, Ertan, TUTAR, Nuri, BILACEROGLU, Senna   +5 more
core   +1 more source

Hypoxic Preconditioning Restores NK Cell Metabolic Fitness by Attenuating MAPK Signaling to Potentiate Antitumor Immunity in Lung Cancer

Advanced Science, EarlyView.
Solid tumor hypoxia severely compromises natural killer cell function. This study demonstrates that hypoxic preconditioning preserves NK cell antitumor activity by limiting excessive stress ‐MAPK signaling and promoting mitochondrial metabolic fitness.
Dian Zhuang, Xiaoyue Zhu, Na Wang, Qianqian Liu, Lihua Chen, Yanzhuo Ye, Lingrui Shang, Shasha Huang, Cong Ma, Wei Kevin Zhang, Tao Xu, Jiaqi Sun, Huisheng Liu   +12 more
wiley   +1 more source

Optimization of diagnostics and treatment of patients with mediastinal malignancy [PDF]

, 2009
В соответствии с поставленной задачей, на основании собственного клинического опыта по диагностике и лечению более 1668 больных с первичными опухолями средостения определены оптимальные варианты морфологи- ческой классификации, диагностики, выбора ...
Ганул, А.В.
core   +2 more sources

Ectopic Thyroid Tissue Presenting as an Anterior Mediastinal Mass in an Elderly Male

Current Medical Issues
A rare developmental defect called ectopic thyroid tissue (ETT) is caused by abnormal embryonic migration. Less than 1% of ectopic thyroid instances are mediastinal ETT, which might radiologically resemble malignant neoplasms.
Maureen Mushtaq, Anuja Sharma
doaj   +1 more source

Mediastinal germ cell tumors

, 2016
The mediastinum is among the most frequent anatomic region in which germ cell tumors (GCT) arise, second only to the gonads. Mediastinal GCT (mGCT) account for 16 % of all mediastinal neoplasms.
Bremmer, Felix, Stroebel, Philipp
core   +1 more source

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma [PDF]

, 2009
Proliferation and survival of Hodgkin and Reed/Sternberg (HRS) cells, the malignant cells of classical Hodgkin lymphoma (cHL), are dependent on constitutive activation of nuclear factor {kappa}B (NF-{kappa}B).
Inga Vater, Giefing, Maciej, Vater, Inga, Hartmann, Sylvia, Martin-Leo Hansmann, Martin-Subero, Jose Ignacio, Bohle, Verena, Küppers, Ralf, Jens Stanelle, Ralf Küppers, Sylvia Hartmann, Gunhild Mechtersheimer, Hansmann, Martin-Leo, Gesk, Stefan, Jose Ignacio Martin-Subero, Stanelle, Jens, Verena Bohle, Siebert, Reiner, Roland Schmitz, Klapper, Wolfram, Maciej Giefing, Wolfram Klapper, Mechtersheimer, Gunhild, Schmitz, Roland, Stefan Gesk, Reiner Siebert   +25 more
core   +1 more source