Results 41 to 50 of about 102,946 (255)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Ectopic Thyroid Tissue Presenting as an Anterior Mediastinal Mass in an Elderly Male

Current Medical Issues
A rare developmental defect called ectopic thyroid tissue (ETT) is caused by abnormal embryonic migration. Less than 1% of ectopic thyroid instances are mediastinal ETT, which might radiologically resemble malignant neoplasms.
Maureen Mushtaq, Anuja Sharma
doaj   +1 more source

Clinical effectiveness and cost-effectiveness of endobronchial and endoscopic ultrasound relative to surgical staging in potentially resectable lung cancer: results from the ASTER randomised controlled trial [PDF]

, 2012
Copyright @ Queen’s Printer and Controller of HMSO 2012. This work was produced by Sharples et al. under the terms of a commissioning contract issued by the Secretary of State for Health.Objective: To assess the clinical effectiveness and cost ...
E Wheaton, Sharples, L. D., Dooms, C., Dooms, C, LD Sharples, Sharples, LD, M Buxton, Deschepper, Ellen, Jackson, C., Rintoul, R. C., Deschepper, E, C Jackson, Magee, L, Annema, JT, Tournoy, K. G., Hughes, V., Wheaton, E., KG Tournoy, RC Rintoul, Hughes, V, L Magee, Buxton, M., C Dooms, Annema, J. T., V Hughes, Magee, L., JT Annema, Buxton, M, Griffith, G, E Deschepper, Tournoy, KG, Tournoy, Kurt, Jackson, C, G Griffith, Deschepper, E., Griffith, G., Wheaton, E, Rintoul, RC   +37 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Mediastinal Desmoid Tumor Presents as Lymphadenopathy in Patient with Lymphoma: A Case Report

Case Reports in Oncology, 2023
Desmoid tumors are rare mesenchymal neoplasms that are rapidly growing but do not metastasize. We present a case of a 75-year-old man with a history of non-Hodgkin lymphoma in remission incidentally found to have an enlarging internal mammary lymph node ...
Tara L. Ballouz, Jeffrey H. Margolis
doaj   +1 more source

Mucinous Neoplasms

, 2022
Mucinous cystic neoplasms (MCNs) are thick-walled, uni- or multilocular tumors composed of mucin-containing cysts. These neoplasms occur almost exclusively in women and are mainly located in the body-tail of the pancreas.
D'Onofrio, Mirko, Capelli, Paola, Martini, Paolo Tinazzi, Barbi, Emilio, Luchini, Claudio, De Robertis, Riccardo   +5 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Surgical management of 32 primary giant mediastinal neoplasms: a retrospective single-center analysis

Journal of Cardiothoracic Surgery
Background Primary giant mediastinal neoplasms are extremely uncommon. Large-sample studies are rare yet urgently needed. Methods We conducted a retrospective analysis of consecutive cases who underwent excision surgery for giant mediastinal neoplasms ...
Qihang Zhu, Zhe He, Jing Zhan, Xiaojing Yao, Shuang Zhao, Kai Chen, Qingrong Ma, Wei Liang, Guibin Qiao, Haiping Xiao   +9 more
doaj   +1 more source

Posthumously Diagnosed Myhre Syndrome Presenting With Pleural Remodeling and Endometrial Cancer

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (OMIM 139210) is a genetic condition defined by neurodevelopmental disability, characteristic facial features, and multisystem proliferative fibrosis. While various types of lung disease have been reported, pleural remodeling leading to restrictive lung disease has not yet been described.
Jeanette Saffir, Karee Morgan, Karigynn Chaimson, Blake E. Funke, Kim L. Sandler, Melissa Hogan, Thomas Cassini   +6 more
wiley   +1 more source