Results 121 to 130 of about 1,318,585 (312)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Big-five personality traits and depression: chain mediation of self-efficacy and walking

Frontiers in Psychiatry
BackgroundDepression is a major global public health concern, with research indicating a correlation between personality traits and depression. This study aimed to explore the potential mediating roles of self-efficacy and walking in the relationship ...
Han Cai, Han Cai, Hongtao Song, Hongtao Song, Yating Yang, Yating Yang, Zihe Xiao, Zihe Xiao, Xianlong Zhang, Xianlong Zhang, Feng Jiang, Feng Jiang, Huanzhong Liu, Huanzhong Liu, Huanzhong Liu, Yi-lang Tang, Yi-lang Tang   +16 more
doaj   +1 more source

Dual Mechanism Mediating Opiate Effects? [PDF]

Science, 1979
S, Amir, R, Blair, P, Shizgal, Z, Amit
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

SOCIOEMOTIONAL SELECTIVITY (FUTURE TIME PERSPECTIVE, GOAL ORIENTATION) AND SUBJECTIVE WELL BEING [PDF]

, 2011
Successful old age is coveted by every individual who enters late adulthood, which is marked by selfassessment of well-being, known as subjective well-being.
Desiningrum, Dinie Ratri
core  

The mediator effectiveness hypothesis revisited [PDF]

Nature Human Behaviour, 2018
Mary A, Pyc, Katherine A, Rawson
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Mediating role of possible sarcopenia in the association between diabetes and stroke: finding from the China health and retirement longitudinal study

BMC Geriatrics
Background Diabetes and sarcopenia were risk factors for the development of stroke. The presence of diabetes increased the likelihood of developing sarcopenia.
Jing Cai, JingMin Qiao, YiRan Liu, HongYan Li, CaiPing Lu, Ying Gao   +5 more
doaj   +1 more source

Impacts of Rural–Urban Labour Transfer and Land Transfer on Land Efficiency in China: A Analysis of Mediating Effects

Land
In the midst of China’s ongoing rural–urban integration and development, a pivotal transformation involving the realignment of labour dynamics and land utilisation is underway.
Siyi Pei, Sudan Zhao, Xuan Li, Jiahui Li
doaj   +1 more source