Immersive experience in virtual reality gamification teaching: analysis of the mediating effect on educational learning outcomes. [PDF]
Sci RepLin J.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The Effects of Physical Exercise on the Social Adaptation of Older Adults-With Reference to the Mediating Effect of Aging Identity. [PDF]
Behav Sci (Basel)Zhang Z, Zhang J, Fu C, Fan C.
europepmc +1 more source
Phonon-mediated Casimir effect
, 2019 The Casimir interaction is the fundamental physical phenomenon which emerges due to modification of vacuum fluctuations by boundaries in a confined area of space. It arises in many fields of physics, including condensed matter. Recently, substantial interest in the Casimir effect has revived as a result of the significant progress in the experimental ...
openaire +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Mediating Effect of Professional Identity Between Psychological Empowerment and Moral Courage of Nursing Students. [PDF]
Nurs OpenHuang M, Wei S, Zhao Q, Dong W, Mo N.
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
SUMOylation mediates brassinosteroid effects [PDF]
Nature Reviews Molecular Cell Biology, 2014 openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The impact of social support on exercise persistence in adolescents: the mediating effect of exercise self-efficacy and autonomic motivation. [PDF]
BMC Public HealthWu Q +8 more
europepmc +1 more source