Results 191 to 200 of about 576,017 (266)

From muscle to brain: the mediating effect of vitamin D in the relationship between muscle loss and cognitive function in Alzheimer's disease. [PDF]

Front Aging Neurosci
Ma X, Yao L, Li F, Cui C, Wang E, Wang C, Zhao P, Weng X, Liu C, Liu S, Hu H.   +10 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Negative and Nonlinear Association Between Particulate Matter and Cardiorespiratory Fitness Among Children and Adolescents: The Mediating Effect of Adiposity. [PDF]

J Am Heart Assoc
Zhang F, Bi CJ, Guo YR, Liu Y, Sun PW, Hong J, Hu YY, Liu H, Hu LX, Zhang YS, Chen YJ, Yin XJ, Ye XM.   +12 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Exploring the Relationship Between Authentic Leadership and Nurses' Caring Behavior: The Mediating Effect of Occupational Coping Self-Efficacy. [PDF]

J Nurs Manag
Chen H, Qiu Y, Wu C, Li X, Wu J, Li L, Yu J, Song J, Shen Q.   +8 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Oral Health Status as a Mediating Effect Between Psychosocial Factors and Oral Health-Related Quality of Life. [PDF]

Int Dent J
Jiang L, Loschke N, Ziebolz D, Reissmann DR, Schmalz G.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Mediating Effect of Sleep Quality on the Association Between Psychological Stress and Acne Vulgaris in Chinese College Students: A Cross-Sectional Study. [PDF]

Healthcare (Basel)
Chen MH, Ma L, Chen LQ, Qin L.
europepmc   +1 more source