Results 141 to 150 of about 1,930,794 (341)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A 125GeV Higgs Boson and Muon g-2 in More Generic Gauge Mediation

, 2012
Recently, the ATLAS and CMS collaborations reported exciting hints of a Standard Model-like Higgs boson with a mass around 125GeV. A Higgs boson this heavy is difficult to realize in conventional models of gauge mediation.
G. F. Giudice, Jason L. Evans, M. Gell- Mann, Masahiro Ibe, Satoshi Shirai, T. Yanagida, Tsutomu T. Yanagida   +6 more
core   +1 more source

A Dnmt2-like protein mediates DNA methylation inDrosophila [PDF]

, 2003
Natascha Kunert, Joachim Marhold, Jonas Stanke, Dirk Stach, Frank Lyko   +4 more
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Supersymmetry breaking

, 2006
These lectures provide a simple introduction to supersymmetry breaking. After presenting the basics of the subject and illustrating them in tree-level examples, we discuss dynamical supersymmetry breaking, emphasizing the role of holomorphy and ...
Affleck, Affleck, Affleck, Cordes, Dine, Dine, Fayet, Ferrara, Giudice, Giudice, Giudice, Grisaru, Harnik, Intriligator, Intriligator, Katz, Luty, Meurice, Nir, ORaifeartaigh, Pomarol, Poppitz, Randall, Seiberg, Shadmi, Wess, Wess, Witten   +27 more
core   +2 more sources

Mediation [PDF]

Baylor University Medical Center Proceedings, 2003
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

How health mediation can function effectively on the fostering of healthcare utilization? : a realist qualitative study

BMC Public Health
Background Health mediation practices are multiform—as they constantly adapt to the context—and multilevel, making any study of health mediation complex.
Elodie Richard, Leila Ramiz, Mara Oltean, Vanina Troussier, Caroline Ulracher, Olivia Speed, Muriele Conort, Cécile Coutant, Fréderique Chaves Quirino, Judith Martin Fernandez, Stéphanie Vandentorren, Linda Cambon   +11 more
doaj   +1 more source

Acetyl-Boswellic Acids Inhibit Lipopolysaccharide-Mediated TNF-α Induction in Monocytes by Direct Interaction with IκB Kinases [PDF]

, 2005
Tatiana Syrovets, Berthold Büchele, Christine Krauss, Yves Laumonnier, Thomas Simmet   +4 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source