Results 141 to 150 of about 1,894,725 (339)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

How health mediation can function effectively on the fostering of healthcare utilization? : a realist qualitative study

BMC Public Health
Background Health mediation practices are multiform—as they constantly adapt to the context—and multilevel, making any study of health mediation complex.
Elodie Richard, Leila Ramiz, Mara Oltean, Vanina Troussier, Caroline Ulracher, Olivia Speed, Muriele Conort, Cécile Coutant, Fréderique Chaves Quirino, Judith Martin Fernandez, Stéphanie Vandentorren, Linda Cambon   +11 more
doaj   +1 more source

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock [PDF]

, 2014
Rui Ye, Cristopher P. Selby, Yi‐Ying Chiou, Irem Ozkan‐Dagliyan, Shobhan Gaddameedhi, Aziz Sancar   +5 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in EnvironmentalAeromonasspp. [PDF]

, 2008
Vincent Cattoir, Laurent Poirel, Camille Aubert, Claude–James Soussy, Patrice Nordmann   +4 more
openalex   +1 more source

C(sp ³ )–H methylation enabled by peroxide photosensitization and Ni-mediated radical coupling

, 2021
Aristidis Vasilopoulos, Shane W. Krska, Shannon S. Stahl   +2 more
openalex   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Family mediation: problems of negotiability and domestic violence in the focus of professional discourse (on the materials of sociological research)

Цифровая социология
The article is devoted to a sociological analysis of the opinions of family mediation specialists on the problems of spousal negotiability and domestic violence.
O. E. Gracheva, I. V. Mkrtumova
doaj   +1 more source

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia [PDF]

, 2019
Paul C. McDonald, Shawn C. Chafe, Wells S. Brown, Saeed Saberi, Mridula Swayampakula, Geetha Venkateswaran, Oksana Nemirovsky, Jordan Gillespie, Joanna M. Karasinska, Steve E. Kalloger, Claudiu T. Supuran, David F. Schaeffer, Ali Bashashati, Sohrab P. Shah, James T. Topham, Donald T. Yapp, Jinyang Li, Daniel J. Renouf, Ben Z. Stanger, Shoukat Dedhar   +19 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source