Results 121 to 130 of about 507,043 (295)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Pre-litigation Mediation as a Privacy Policy: Exploring the Interaction of Economics and Privacy [PDF]
Pre-litigation mediation is a perfect example of the economic trade-offs that exist in privacy policy. In pre-litigation mediation, costs and confidentiality work independently.
Costello, Thomas J (TJ)
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Peer Mediators’ Perceptions of the Mediation Process
Education and Science, 2011 Bu araştırmanın amacı, arkadaşlarının anlaşmazlıklarında arabuluculuk yapan lise öğrencilerinin süreç ile ilgili deneyimlerini, onların bakış açısından incelemektir. Araştırma, nitel araştırma tekniklerinden yarı yapılandırılmış görüşme tekniği kullanılarak gerçekleştirilmiştir. Araştırmada 45 arabulucu öğrenci ile çalışılmıştır. Toplanan nitel veriler
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Mediation and Conflict Management [PDF]
Mediation is a popular process to manage conflicts, but there is little systematic insight into its mechanisms. This paper discusses the results from an experiment in which a mediator can induce two conflict parties to behave cooperatively.
Gerald Eisenkopf
core
Jurnal Ilmu Sosial dan Ilmu PolitikSocial conflicts in Madurese society are deeply intertwined with the value of ghengghu’ (honor) as a moral foundation for preserving human dignity and community relations.
Naqiah Naqiah +3 more
doaj +1 more source
Mediation Functions Performed by Mediator during Mediation. Selected Problems
Studia Iuridica Lublinensia, 2018 The subject of this article is the analysis of the activity undertaken during mediation in the context of the characteristics of the mediation process and the normative conditions of the legal relationship and disputes resolved through this form of ADR.
openaire +2 more sources