Results 241 to 250 of about 1,930,794 (341)

ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1

, 2019
Justin P. Ingram, Roshan J. Thapa, Amanda Fisher, Bart Tummers, Ting Zhang, Chaoran Yin, Diego A. Rodríguez, Hongyan Guo, Rebecca Lane, Riley Williams, Michael Slifker, Suresh H. Basagoudanavar, Glenn F. Rall, Christopher P. Dillon, Douglas R. Green, William J. Kaiser, Siddharth Balachandran   +16 more
openalex   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Replacement fibrosis, left ventricular ejection fraction and sudden cardiac death in patients after myocardial infarction: a mediation analysis. [PDF]

Open Heart
Zhou P, Aisikaier K, Dong Z, Ma X, Tang Y, Wei Z, Jia X, Chen X, Liu Y, Xu W, Sa F, Yang SJ, Wang J, Zhao F, Lu M, Zhao X, Chen X, Zhao S.   +17 more
europepmc   +1 more source

Operando Monitoring of the Solution-Mediated Discharge and Charge Processes in a Na–O₂ Battery Using Liquid-Electrochemical Transmission Electron Microscopy

, 2018
Lukas Lutz, Walid Dachraoui, Arnaud Demortière, Lee Johnson, Peter G. Bruce, Alexis Grimaud, Jean‐Marie Tarascon   +6 more
openalex   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Are Maternal Adverse Childhood Experiences Associated with Their Preschool Children's Sleep Disruptions? Longitudinal Mediation Through Mothers' Depressive Symptoms and Children's Screen Time. [PDF]

Children (Basel)
Kurbatfinski S, Nandakumar L, Lee JB, Giesbrecht GF, Letourneau N.   +4 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ProteoNexus: an integrative database to characterize genetic architecture, estimate mediation effects, and construct and evaluate prediction models of the plasma proteome. [PDF]

Nucleic Acids Res
Shao K, Luo Z, Huang P, Yang S.
europepmc   +1 more source

Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization

, 2019
Steven A. Hill, Andrew S Blaeser, Austin A. Coley, Yajun Xie, Katherine A. Shepard, Corey C. Harwell, Wen‐Jun Gao, A. Denise R. Garcia   +7 more
openalex   +1 more source

CBL1‐CIPK26‐mediated phosphorylation enhances activity of the NADPH oxidase RBOHC, but is dispensable for root hair growth [PDF]

, 2018
Xinxin Zhang, Philipp Köster, Kathrin Schlücking, Daria Balcerowicz, Kenji Hashimoto, Kazuyuki Kuchitsu, Kris Vissenberg, Jörg Kudla   +7 more
openalex   +1 more source