Results 71 to 80 of about 3,869,309 (345)
FEBS Letters, EarlyView.Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki +4 more
wiley +1 more source
Causal Mediation Programs in R, Mplus, SAS, SPSS, and Stata
Structural equation modeling : a multidisciplinary journal, 2020 Mediation analysis is a methodology used to understand how and why an independent variable (X) transmits its effect to an outcome (Y) through a mediator (M).
Matthew J. Valente +4 more
semanticscholar +1 more source
Flexible Mediation Analysis With Multiple Mediators [PDF]
American Journal of Epidemiology, 2017 The advent of counterfactual-based mediation analysis has triggered enormous progress on how, and under what assumptions, one may disentangle path-specific effects upon combining arbitrary (possibly nonlinear) models for mediator and outcome. However, current developments have largely focused on single mediators because required identification ...
Johan Steen +3 more
openaire +3 more sources
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
Precontractual Agreements in Selected Legal Systems
Baltic Journal of European studies, 2020 Certain legal instruments have been developed in business transactions in order to facilitate the conclusion of an agreement under negotiation. The instruments of this kind are called precontractual agreements.
Sławicki Piotr
doaj +1 more source
Entangled Religions, 2020 Why and how is it productive to conceptualize religion as mediation? In this article, I 1) rehearse the intellectual trajectory of the move from studying the implications of the adoption of new mass media into religious practices to a broader idea of religion as a practice of mediation; 2) address some criticisms raised with regard to the concept of ...
openaire +5 more sources
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
Journal of High Energy Physics, 2013 32 pages, 3 figures, references added, minor ...
Baryakhtar, M +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source