Results 251 to 260 of about 22,390,894 (295)

Workplace management practices and quiet quitting among primary healthcare workers: a sequential-parallel mediation analysis. [PDF]

Front Public Health
Xia L, Yu Z, Fan S, Xu Q.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Domain-specific and generalised motivational pathways to STEM degree attainment: a 10-year longitudinal mediation analysis. [PDF]

Front Psychol
Yang M.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Industrial action and emergency department attendances in England, 2022-2024: a retrospective multicentre causal mediation analysis. [PDF]

J R Soc Med
Wyatt S, Mohammed MA, Clarke J, Garcia-Fiñana M, Buchan I.   +4 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Anthropometric traits, metabolic biomarkers, and pancreatic cancer risk: a causal mediation analysis in UK Biobank. [PDF]

Br J Cancer
Amadou A, Freisling H, Mercoeur B, Bohmann P, Stein MJ, Noh H, Gebremariam A, Sedlmeier AM, Peruchet-Noray L, Gan Q, Leitzmann MF, Baurecht H, Fervers B.   +12 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The role of psychological flexibility in the relationship between empathy and flourishing among clinical nurses: a cross-sectional mediation analysis. [PDF]

Front Psychol
Guo X, Liu L, Lv H, Lin M, Chen L, Zhang H, Liu M, Liu Y, Jiang W, Liu X.   +9 more
europepmc   +1 more source

Extended working hours, income, and multidimensional wellbeing among physicians in China: a cross-sectional mediation analysis. [PDF]

Front Public Health
Zheng H, Li M, Tang H, Zhou Y, Liu X.
europepmc   +1 more source