Results 91 to 100 of about 6,996 (305)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Moodle en contexte d’enseignement/apprentissage du FLE à l’université algérienne : quelles formes de médiatisation déployées ? [PDF]

open access: yesAkofena
Résumé: A travers cette étude, nous élucidons les formes de médiatisation préconisées par les enseignants-chercheurs de FLE en contexte universitaire algérien.
Amal KADJA & Ilhem BENSLIMANE
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Are we talking the Same Language? Challenging Complexity in Country Brand Models [PDF]

open access: yes, 2014
The purpose of this paper is to review recent research into country brand models and identify the most common and shared dimensions. Based on the literature review, this study establishes a conceptual framework to consider the complex interaction between
Mariutti, F, Tench, R
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Inventaire d'aides dans les environnements multimédias d'apprentissage et propositions d'aides multimodales

open access: yesALSIC: Apprentissage des Langues et Systèmes d'Information et de Communication, 2007
Starting from the hypothesis that multimodality has a role to play in help offers, this article gives an analysis of help guides on offer within a corpus of CD-Roms and web sites which aim to teach French as a foreign language. Then, based on the results
Laurence Hamon
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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