Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
A trans -Dominant Form of Gag Restricts Ty1 Retrotransposition and Mediates Copy Number Control [PDF]
, 2015 Agniva Saha +6 more
openalex +1 more source
Mediation of Conflicts – a Viable Solution for Surpassing Communication Barriers. President-Mediator in the Conflict between the Government and the Syndicate’s Organizations from the Education Field [PDF]
The premises of this project are that approximately 90% of the conflicts in the modern society and not only, are based on poor communication. Any type of miscommunication (due to cultural, linguistic, politic or religious differences) can and will ...
Laura Maria MARUSCA
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
TIGAR induces p53-mediated cell-cycle arrest by regulation of RB–E2F1 complex [PDF]
, 2012 Esha Madan +5 more
openalex +1 more source
On Partial Identification of the Pure Direct Effect [PDF]
, 2015 In causal mediation analysis, nonparametric identification of the pure (natural) direct effect typically relies on, in addition to no unobserved pre-exposure confounding, fundamental assumptions of (i) so-called "cross-world-counterfactuals" independence
Kanki, Phyllis +3 more
core +3 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Clathrin is required for Scar/Wave-mediated lamellipodium formation [PDF]
, 2011 Jérémie Gautier +11 more
openalex +1 more source
Mediators of mechanotransduction between bone cells [PDF]
, 2009 Mechanical forces are known to regulate the function of tissues in the body, including bone. Bone adapts to its mechanical environment by altering its shape and increasing its size in response to increases in mechanical load associated with exercise, and
Komarova, S. V. +4 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source