Results 291 to 300 of about 5,004,571 (383)

Epigenome-wide mediation analysis identified Cytosine-phosphate-Guanine sites linking environmental factors with diabetes indicators. [PDF]

Epigenomics
Lin WY.
europepmc   +1 more source

Decision letter: A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

, 2016

openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Engineered PVA Hydrogel as a Universal Platform for Developing Stable and Sensitive Microbial BOD-Biosensors. [PDF]

Biosensors (Basel)
Medvedeva A, Titova A, Kharkova A, Perchikov R, Gurkin G, Asulyan L, Perelomov L, Gertsen M, Arlyapov V.   +8 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Intergenerational transmission of violence in Bangladesh: Mediated through maternal attitudes towards intimate partner violence, disciplinary beliefs, and life satisfaction. [PDF]

PLoS One
Fahim AU, Aboni A, Munira S, Toosty NT.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Disaster-related home loss, mental health, and risk of cognitive disability: causal mediation analysis using longitudinal data of disaster survivors. [PDF]

Am J Epidemiol
Okuzono SS, Shiba K, Shiba K, Zhu DT, Oh S, Hsu YT, Yazawa A, Hikichi H, Aida J, Kondo K, Tiemeier H, Kawachi I.   +11 more
europepmc   +1 more source

No we don’t have WiFi. Talk to each other: Understanding the dynamics of computer-mediated communication and its impact on well-being

, 2015
Andrew Maile
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source