Results 81 to 90 of about 1,219,522 (300)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Electroweak Baryogenesis and Dark Matter via a Pseudoscalar vs. Scalar
, 2017 We study the electroweak baryogenesis in a fermionic dark matter scenario with a (pseudo)scalar being the mediator in the Higgs portal. It is discussed that the electroweak phase transition turns to be first-order after taking into account the role of ...
Ghorbani, Parsa Hossein
core +1 more source
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Exploring light mediators with low-threshold direct detection experiments [PDF]
, 2017 We explore the potential of future cryogenic direct detection experiments to determine the properties of the mediator that communicates the interactions between dark matter and nuclei.
Kahlhoefer, Felix +2 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Coherent spin-exchange via a quantum mediator
, 2016 Coherent interactions at a distance provide a powerful tool for quantum simulation and computation. The most common approach to realize an effective long-distance coupling 'on-chip' is to use a quantum mediator, as has been demonstrated for ...
Baart, T. A. +4 more
core +1 more source
Minimal self-interacting dark matter models with light mediator
, 2020 The light mediator scenario of self-interacting dark matter is strongly constrained in many ways. After summarizing the various constraints, we discuss minimal options and models which allow to nevertheless satisfy all these constraints.
Hambye, Thomas, Vanderheyden, Laurent
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Minimal Spin-3/2 Dark Matter in a simple $s$-channel model
, 2016 We consider a spin~-~3/2 fermionic dark matter candidate (DM) interacting with Standard Model fermions through a vector mediator in the $s$-channel. We find that for pure vector couplings almost the entire parameter space of the DM and mediator mass ...
Cornell, Alan S. +3 more
core +2 more sources