Results 121 to 130 of about 13,541,940 (307)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Indian Journal of Community MedicineBackground: Internet addiction has become a very common disorder because of which youngsters are wasting a lot of time, becoming irritable and depressed and having poor academic/ work performance and are becoming victims of social isolation.
Smita M Nimbannavar
doaj +1 more source
Prescribe medication…Withdraw medication
Turkish Journal of Gastroenterology, 2016 It may be curious sometimes how in the standard medical practice, our patients come to figure out the aetiology of certain gastrointestinal symptoms, and somehow the consequent pursuing of quick solutions, from a therapeutic point of view.
openaire +2 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Indian Journal of Community MedicineBackground: Smartphones have become an indispensable necessity for medical students because of their various demands and comforts. The excessive use of smartphones may lead to addiction which can negatively affect physical and mental health including ...
Indu Dinesh, K S Ravish, T S Ranganath
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Resolving Medical Disputes: Lessons from U.S. Arbitration for Indonesia’s Legal Framework
Hasanuddin Law ReviewArbitration serves as a dispute resolution method that offers notable benefits, especially in cases related to medical issues. In contrast, other methods such as litigation are often seen as less effective, while mediation lacks executory power due to ...
Muhammad Fakih +4 more
doaj +1 more source
Medical Center grounds diagram
This glass lantern slide features a black and white diagram of the Medical College of South Carolina Medical Center ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source